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Table 2 Altered expression/mutation of F-BAR proteins in diseases and developmental disorders

From: F-BAR family proteins, emerging regulators for cell membrane dynamic changes—from structure to human diseases

Diseases and disorders Species F-BAR protein changes PMID ID#
Developmental and vascular disorders    
 Embryonic defects Drosophila, zebrafish CIP4↑, PACSIN3↓ 23424199, 19997509
 Dorsoventral defects Zebrafish FCHO1↓ 22484487
 Vascular defects Zebrafish NOSTRIN↓ 22751148
 Postnatal retinal angiogenisis Mice NOSTRIN↓ 22751148
Neurological disorders    
 Neurodevelopmental disorders Mice srGAP2↓, srGAP3↓ 23505444, 22820399
 3p syndrome Human srGAP3 deletion 19760623
 Huntington’s disease Human CIP4↑, PACSIN1↓ 12604778, 23852340
 Epileptic seizures Mice PACSIN1↓ 21926968
Autoinflammatory diseases    
 Wiskott-Aldrich syndrome Human FBP17↓ 19155218
 PAPA syndrome Human PSTPIP1 mutation 21532836
 Chronic multifocal osteomyelitis Mice PSTPIP2 mutation 16122996
 Bladder tumor Human FBP17↑ 21421245
 Breast tumor Human CIP4↓ 21525036
 Leukemia Human FBP17↑, FES/FER↑, FCHSD2 11438682, 22201778, 22902056
Cardiac hypertrophy Rat CIP4↑ 23915320
Glucose uptake elevation Rat, mice CIP4↓, PACSIN3↑ 19509061, 17320047
Renal dysfunction Human CIP4↑ 22745576
  1. F-BAR protein expression and mutations are observed in various disease and developmental disorders in human, mice, rat, zebrafish, and drosophila in publications cited by PMID#. FCHSD2 was found differentially expressed in a cardiovascular disease system in our recent study. Abbreviations: 3p syndrome, 3p25-p26 deletion syndrome; PAPA syndrome, Pyogenic arthritis, pyoderma gangrenosum, and acne syndrome.