Proteins | Changes | Disease/condition | Species | Mechanisms | PMID ID# |
---|---|---|---|---|---|
1. CIP4 subfamily | |||||
CIP4 | ↑ | Embryogenesis | Drosophila | Inhibits actin nucleation associated with Diaphanous | 23424199 |
↑ | Huntington’s disease | Human | Induces striatal neuron death | 12604778 | |
↓ | Breast tumor | Human | Suppresses Src-induced tumor cell invasion | 21525036 | |
↓ | Cardiac hypertrophy | Rat | Inhibits myocyte hypertrophy | 23915320 | |
↓ | Glucose uptake | Rat | Induces glucose uptake via GLUT4 endocytosis | 19509061 | |
FBP17 | ↑ | Leukemia | Human | A fusion partner of mixed lineage leukemia | 11438682 |
↓ | Bladder tumor | Human | Inhibits bladder tumor cell invasion | 21421245 | |
↓ | Wiskott-Aldrich syndrome | Human | Suppresses podosomes/phagocytic cup formation | 19155218 | |
2. FCHO subfamily | |||||
FCHO1 | ↓ | Dorsoventral defects | Zebrafish | Suppresses Bmp signal transmission | 22484487 |
3.srGAP subfamily | |||||
srGAP2 | ↓ | Neuronal development | Mice | Suppresses neuronal development through srGAP3 | 23505444 |
srGAP3 | ↓ | Neuronal development | Mice | Induces basal activity of Rac1 | 22820399 |
Deletion | 3p syndrome | Human | Gene is deleted, mechanism not analyzed | 19760623 | |
4. PACSIN subfamily | |||||
PACSIN1 | ↓ | Epileptic seizures | Mice | Induces hippocampal network activity | 21926968 |
↓ | Huntington’s disease | Human | Induces age inappropriate synapse destablization | 23852340 | |
PACSIN3 | ↓ | Embryonic defects | Zebrafish | Suppresses early formation of notochord | 19997509 |
↑ | Glucose uptake | Mice | Induces glucose uptake via GLUT1 trafficking | 17320047 | |
5. PSTPIP subfamily | |||||
PSTPIP1 | Mutation | PAPA syndrome | Human | Gene mutation alters WASP activity | 21532836 |
PSTPIP2 | Mutation | Chronic multifocal osteomyelitis | Mice | Gene mutation and IL-1β induces inflammation | 16122996 |
6. FCHSD subfamily | |||||
FCHSD2 | ↑ | Leukemia | Human | Increases leukemia chemoresistance | 22902056 |
7. FES/FER subfamily | |||||
FES/FER | ↑ | Leukemia | Human | Induces growth and survival signaling in leukemia | 22201778 |
8. NOSTRIN subfamily | |||||
NOSTRIN | ↓ | Postnatal retinal angiogenisis | Mice | Suppresses endothelial tip cell migration | 22751148 |