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Table 3 F-BAR proteins changes and potential mechanisms in diseases and pathophysiological conditions

From: F-BAR family proteins, emerging regulators for cell membrane dynamic changes—from structure to human diseases

Proteins Changes Disease/condition Species Mechanisms PMID ID#
1. CIP4 subfamily      
 CIP4 ↑ Embryogenesis Drosophila Inhibits actin nucleation associated with Diaphanous 23424199
  ↑ Huntington’s disease Human Induces striatal neuron death 12604778
  ↓ Breast tumor Human Suppresses Src-induced tumor cell invasion 21525036
  ↓ Cardiac hypertrophy Rat Inhibits myocyte hypertrophy 23915320
  ↓ Glucose uptake Rat Induces glucose uptake via GLUT4 endocytosis 19509061
 FBP17 ↑ Leukemia Human A fusion partner of mixed lineage leukemia 11438682
  ↓ Bladder tumor Human Inhibits bladder tumor cell invasion 21421245
  ↓ Wiskott-Aldrich syndrome Human Suppresses podosomes/phagocytic cup formation 19155218
2. FCHO subfamily      
 FCHO1 ↓ Dorsoventral defects Zebrafish Suppresses Bmp signal transmission 22484487
3.srGAP subfamily      
 srGAP2 ↓ Neuronal development Mice Suppresses neuronal development through srGAP3 23505444
 srGAP3 ↓ Neuronal development Mice Induces basal activity of Rac1 22820399
  Deletion 3p syndrome Human Gene is deleted, mechanism not analyzed 19760623
4. PACSIN subfamily      
 PACSIN1 ↓ Epileptic seizures Mice Induces hippocampal network activity 21926968
  ↓ Huntington’s disease Human Induces age inappropriate synapse destablization 23852340
 PACSIN3 ↓ Embryonic defects Zebrafish Suppresses early formation of notochord 19997509
  ↑ Glucose uptake Mice Induces glucose uptake via GLUT1 trafficking 17320047
5. PSTPIP subfamily      
PSTPIP1 Mutation PAPA syndrome Human Gene mutation alters WASP activity 21532836
PSTPIP2 Mutation Chronic multifocal osteomyelitis Mice Gene mutation and IL-1β induces inflammation 16122996
6. FCHSD subfamily      
FCHSD2 ↑ Leukemia Human Increases leukemia chemoresistance 22902056
7. FES/FER subfamily      
FES/FER ↑ Leukemia Human Induces growth and survival signaling in leukemia 22201778
8. NOSTRIN subfamily      
NOSTRIN ↓ Postnatal retinal angiogenisis Mice Suppresses endothelial tip cell migration 22751148
  1. F-BAR protein expression is observed in various disease and pathophysiological conditions via suggested mechanisms in human, mice, rat, zebrafish, and drosophila. Relevant publications are cited by PMID#. For other abbreviations, refer to Table 2.
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Journal of Hematology & Oncology

ISSN: 1756-8722

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