Skip to main content
Fig. 2 | Journal of Hematology & Oncology

Fig. 2

From: Targeting Wnt pathway in mantle cell lymphoma-initiating cells

Fig. 2

Stem cell-like properties of MCL-ICs. ac qRT-PCR performed using the total cellular RNA isolated from MCL-ICs (n = 4) for a stem cell transcription factors (Nanog, Oct4, Sox2, Klf4), b ALDH isoforms and antioxidant enzymes SOD2 and MT1b, and c chemoresistance-associated genes encoding ABCC3, ABCC6, and CD44. Differences between MCL-ICs and MCL-non-ICs were significant (P < 0.05) for ALDH1, ALDH2, SOD2, MT1b, Nanog, Oct4, Klf4, ABCC3, ABCC6, and CD44. d Cell cycle analysis of isolated MCL-ICs, MCL-non-ICs, and total MCL cells by flow cytometry. e ALDH activity in freshly isolated MCL-ICs from apheresis samples evaluated using ALDEFLUOR kit

Back to article page