Fig. 3

BCR signaling cascades in the a absence and b presence of antigen. Protein kinases are shown in red and the lipid kinase PI3Kδ in blue [38]. BCR B-cell receptor, BTK Bruton’s tyrosine kinase, Ig immunoglobulin, IKK I kappa B kinase, NF nuclear factor, NFAT nuclear factor of activated T cells P phosphorylation, PI3Kδ phosphatidylinositol 3-kinase, PKC protein kinase C, PLC phospholipase C, SYK spleen tyrosine kinase. From [38]