Fig. 6

The effect of vincristine and SAHA on the MOLT-4 tumor xenograft. SCID mice were ectopically implanted with MOLT-4 cells, and when the tumor size reached 100 mm³, mice were injected with vincristine (i.p., qwk) or SAHA (p.o., qd) alone or a combination of both. a In vivo antitumor efficacy was expressed as tumor growth delay (TGD) (vincristine 0.1 mg/kg i.v. qwk; SAHA 50 mg/kg p.o. qd). b Effects of combination on tumor volume. The growth curves are the means of the tumor sizes measured with each group (vincristine 0.025 mg/kg i.v. qwk; SAHA 200 mg/kg p.o. qd). c The remaining percentage of mice survival (vincristine 0.1 mg/kg i.v. qwk; SAHA 50 mg/kg p.o. qd). d Effects of combined treatment on mice body weight (vincristine 0.025 mg/kg i.v. qwk; SAHA 200 mg/kg p.o. qd). e Tumors were resected for the western blot analysis (vincristine 0.025 mg/kg i.v. qwk; SAHA 200 mg/kg p.o. qd)