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Table 2 Multivariate analysis of factors associated with transplant outcomes

From: Donor-specific anti-human leukocyte antigen antibodies were associated with primary graft failure after unmanipulated haploidentical blood and marrow transplantation: a prospective study with randomly assigned training and validation sets

  HR 95 % CI P value
Primary graft failure    
 DSA    
  MFI ≥ 10,000 1   
  2000 ≤ MFI < 10,000 0.940 0.284–3.177 0.919
  MFI < 2000 0.187 0.048–0.730 0.016
OS    
 Disease status 2.839 1.702–4.736 0.000
 Primary graft failure    
  GR 1   
  PGF 0.271 0.074–1.000 0.050
  No primary graft failure 0.068 0.020–0.229 0.000
DFS    
 Disease status 3.593 2.212–5.836 0.000
 PGF 3.125 1.564–6.244 0.000
  GR 1   
  PGF 0.284 0.077–1.044 0.058
  No primary graft failure 0.084 0.025–0.279 0.000
Relapse    
 Disease status 9.906 4.099–23.940 0.000
TRM    
 PGF    
  GR 1   
  PGF 0.209 0.056–0.790 0.021
  No primary graft failure 0.031 0.0009–0.107 0.000
ANC    
 CD34 1.370 1.106–1.697 0.004
PLT    
 CD34 1.483 1.187–1.852 0.001
 DSA    
  MFI ≥ 10,000 1   
  2000 ≤ MFI < 10,000 3.074 1.137–8.311 0.027
  MFI < 2000 3.301 1.358–8.022 0.008
  1. Abbreviations: HR hazard ratio, CI confidence interval, DSAs donor-specific antibodies, MFI median fluorescence intensity, OS overall survival, GR graft rejection, PGF poor graft function, DFS disease-free survival, TRM transplant-related mortality, ANC absolute neutrophil count, PLT platelet