Table 1 Overview of clinical trials investigating the therapeutic usefulness of the UPR
From: Drugging the unfolded protein response in acute leukemias
Compound | Molecular target | Disease | Stage of clinical development | References |
|---|---|---|---|---|
Epigallocatechin gallate (EGCG) | GRP78 | Alzheimer’s disease | Clinical, phase 2 and 3 | NCT00951834 |
PAT-SM6 | GRP78 | Multiple myeloma | Clinical, phase 1 | NCT01727778, Rasche et al. [115] |