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Table 1 Overview of clinical trials investigating the therapeutic usefulness of the UPR

From: Drugging the unfolded protein response in acute leukemias

Compound Molecular target Disease Stage of clinical development References
Epigallocatechin gallate (EGCG) GRP78 Alzheimer’s disease Clinical, phase 2 and 3 NCT00951834
PAT-SM6 GRP78 Multiple myeloma Clinical, phase 1 NCT01727778, Rasche et al. [115]