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Table 2 Overview of preclinical studies studying the therapeutic usefulness of the UPR

From: Drugging the unfolded protein response in acute leukemias

Compound Molecular target Disease Stage of clinical development References
STF-083010 IRE-1 Multiple myeloma Preclinical Papandreou et al. [99]
ALL Kharabi Masouleh et al. [87]
CLL Kriss et al. [116]
A106 IRE-1 CLL Preclinical Kriss et al. [116]
ALL Kharabi Masouleh et al. [87]
MKC-3946 IRE-1 Multiple myeloma Preclinical Volkmann et al. [100]
Mimura et al. [101]
4μ8c IRE-1 Multiple myeloma Preclinical Cross et al. [102]
GSK2606414 PERK Multiple myeloma Preclinical Axten et al. [98]
GSK2656157 Pancreatic cancer
Epigallocatechin gallate (EGCG) GRP78 ALL Preclinical Uckun et al. [111]
PAT-SM6 GRP78 Melanoma Preclinical Rosenez et al. [113]
Multiple myeloma Rasche et al. [114]
Pep42 GRP78 ALL Preclinical Uckun et al. [111]