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Table 2 Overview of preclinical studies studying the therapeutic usefulness of the UPR

From: Drugging the unfolded protein response in acute leukemias

Compound

Molecular target

Disease

Stage of clinical development

References

STF-083010

IRE-1

Multiple myeloma

Preclinical

Papandreou et al. [99]

ALL

Kharabi Masouleh et al. [87]

CLL

Kriss et al. [116]

A106

IRE-1

CLL

Preclinical

Kriss et al. [116]

ALL

Kharabi Masouleh et al. [87]

MKC-3946

IRE-1

Multiple myeloma

Preclinical

Volkmann et al. [100]

Mimura et al. [101]

4μ8c

IRE-1

Multiple myeloma

Preclinical

Cross et al. [102]

GSK2606414

PERK

Multiple myeloma

Preclinical

Axten et al. [98]

GSK2656157

Pancreatic cancer

Epigallocatechin gallate (EGCG)

GRP78

ALL

Preclinical

Uckun et al. [111]

PAT-SM6

GRP78

Melanoma

Preclinical

Rosenez et al. [113]

Multiple myeloma

Rasche et al. [114]

Pep42

GRP78

ALL

Preclinical

Uckun et al. [111]