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Fig. 4 | Journal of Hematology & Oncology

Fig. 4

From: TMEM140 is associated with the prognosis of glioma by promoting cell viability and invasion

Fig. 4

Depletion of TMEM140-induced apoptosis of glioma cells. a GSEA was performed using the TCGA GBM dataset. The cell apoptosis pathway was positive associated with TMEM140 higher expression. b U87 and U373 cells were transfected with indicated siRNA. Cells were harvest after 48 h, double labeled with Annexin V-FITC and PI, and analyzed using flow cytometry. c, d The expression levels of three apoptotic factors (cleaved caspase, Bax and Bcl2) were evaluated by western blot analysis. The representative images are shown in the left panel, and data from three independent experiments are expressed as the mean ± S.D. (right panel) (*P < 0.05, ** P < 0.01, ***P < 0.001 compared with the normal controls)

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