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Fig. 5 | Journal of Hematology & Oncology

Fig. 5

From: TMEM140 is associated with the prognosis of glioma by promoting cell viability and invasion

Fig. 5

TMEM140 silencing suppressed adhesion, migration, and invasion in the glioma cells. a Based on the TCGA GBM dataset, GSEA showed that KEGG cell adhesion molecules were positively associated with higher TMEM140 expression levels. The cells were transfected with normal control or TMEM140-RNAi for 48 h and subjected to cell adhesion, migration, and invasion assay. b TMEM140 knockdown inhibited glioma cell adhesion. c TMEM140 knockdown inhibited the migration abilities of glioma cells. d TMEM140 knockdown suppressed the invasive abilities of the glioma cells. The representative images are shown in the upper panel, and data from three independent experiments are expressed as the mean ± S.D. e, f Expression levels of cell adhesion molecules, ICAM1, VCAM1, and Syndecan1 were evaluated by Western blot analysis (lower panel). (*P < 0.05, **P < 0.01, ***P < 0.001 compared with the normal controls)

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