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Fig. 3 | Journal of Hematology & Oncology

Fig. 3

From: T cells are functionally not impaired in AML: increased PD-1 expression is only seen at time of relapse and correlates with a shift towards the memory T cell compartment

Fig. 3

Upregulation of PD-1 expression on bone marrow T cells of AML patients at relapse after allogeneic SCT compared to diagnosis. Expression of CD244 (a, e), PD-1 (b, f), CD160 (c, g), and TIM-3 (d, h) was measured on bone marrow CD8+ (ad) and CD4+ (eh) T cells of 31 AML patients at diagnosis (AML_diag), 7 patients with an AML relapse after intensive chemotherapy (AML_rel), and 6 patients with an AML relapse after allogeneic SCT (AML_rel_allo) in comparison to 5 healthy controls (HC), and percentages of positive cells were depicted. Patient selection was limited to the age cohort >40 years. Statistical differences were calculated to HC and AML_diag. *p ≤ 0.05; **p ≤ 0.01; ***p ≤ 0.001; ****p ≤ 0.0001

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