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Fig. 6 | Journal of Hematology & Oncology

Fig. 6

From: T cells are functionally not impaired in AML: increased PD-1 expression is only seen at time of relapse and correlates with a shift towards the memory T cell compartment

Fig. 6

Functional integrity of T cells from AML patients. Proliferation (a, b) and production of IFN-γ (c, d), TNF-α (e, f), and IL-2 (g, h) with or without an unspecific stimulus were analyzed for peripheral blood CD8+ (a, c, e, g) and CD4+ (b, d, f, h) T cells of AML patients at diagnosis (AML_diag; n = 7 for proliferation and n = 11 for cytokines), patients with an AML relapse after intensive chemotherapy (AML_rel; n = 5 and n = 7), and patients with an AML relapse after allogeneic SCT (AML_rel_allo; n = 3 and n = 4) in comparison to healthy controls (HC; n = 8 and n = 20). Four HIV patients (HIV) served as an additional control for diminished cytokine production. Percentages of divided (a, b) or of positive (ch) cells were depicted. Statistical differences were calculated to HC. *p ≤ 0.05; **p ≤ 0.01; ***p ≤ 0.001; ****p ≤ 0.0001

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