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Fig. 1 | Journal of Hematology & Oncology

Fig. 1

From: Haploinsufficiency of Bcl11b suppresses the progression of ATM-deficient T cell lymphomas

Fig. 1

Heterozygous loss of Bcl11b suppresses the progression, but not the initiation of ATM-deficient thymic lymphomas. a Thymic lymphoma-free survival of ATM−/− and ATM−/−Bcl11b+/− mice. Median survival of ATM−/− and ATM−/−Bcl11b+/− cohorts was 106 and 169 days, respectively. p value for log-ranking test is 0.0061. b Representative flow cytometry analyses of the thymus from control and ATM−/−Bcl11b+/− mice at 3 or 10 months of age. c Southern blot analyses of EcoRI digested genomic DNA from kidney (K), thymus (T), enlarged submandibular lymph nodes (L), or spleen (S) from ATM−/−Bcl11b+/− mice probed with TCRβ probes (Jβ1.6 or 2.7), TCRδ constant region (Cδ) or chromosome 14 amplification region (Amp) [6]. d Southern blot analyses of Bcl11b locus on KpnI digested genomic DNA with Bcl11b probe [13]

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