Fig. 1
From: JAK kinase inhibitors for the treatment of acute lymphoblastic leukemia
Schematic representation of the interleukin-7 (IL7) receptor signaling complex. Arrows indicate locations that are often found to be mutated. Activation of the receptor complex by ligand binding or by mutation in IL7R, JAK1, or JAK3 causes phosphorylation of STAT proteins, which leads to activation of survival and proliferation pathways