Fig. 7

Possible mechanisms of Sal-YB1-induced cytotoxic effects on neuroblastoma. Bio-engineered Salmonella with the assistance of macrophages should contribute to the neuroblastoma reducing progression. TNFα release from macrophages is likely to be one of the cytotoxic components. Abbreviation: TLR4 toll-like receptor 4, MyD88 myeloid differentiation primary response gene 88, IRAK interleukin 1 receptor-associated kinase, TAK1 TGF-β-activated kinase 1, IκBα nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor alpha, IKK IκB kinase, NF-kB nuclear factor kappa B, TNFα tumor necrosis factor alpha, TNFR tumor necrosis factor receptor, TNFAIP6 tumor necrosis factor alpha-induced protein 6, TSG6 TNF-stimulated gene 6 protein, Casp. caspase