Fig. 3

Representative MRI scans show that genetic alteration of EphA4/EphA7 genotype yields no consistent effect on tumor size in the Smo medulloblastoma animal model. EphA4 ^−/− EphA7 ^−/− Smo mice and their EphA4 ^+/− EphA7 ^−/− Smo and EphA4 ^+/+ EphA7 ^−/− Smo littermate controls were followed by serial MRI. Representative images are shown for a EphA4 ^+/+ EphA7 ^−/− Smo, EphA4 ^+/− EphA7 ^−/− Smo, and EphA4 ^+/− EphA7 ^−/− Smo pairs. b Volumetric tumor growth analysis. Data represent mean ± standard deviation from different tumor tissues. (p = not significant)