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Fig. 4 | Journal of Hematology & Oncology

Fig. 4

From: Redirection of CD4+ and CD8+ T lymphocytes via an anti-CD3 × anti-CD19 bi-specific antibody combined with cytosine arabinoside and the efficient lysis of patient-derived B-ALL cells

Fig. 4

IL3, TNFα, and IFNγ released by activated T cell subpopulation. CD4+ or CD8+ T cells incubated with tumor target cells and the diabody or ds-diabody (10 pM) released higher amounts of IL3 (a, b), TNFα (c, d), and IFNγ (e, f). Tumor cells incubated with Ara-C stimulated CD4+ or CD8+ T cells, releasing the highest IL3, TNFα, and IFNγ amounts in the presence of diabody or ds-diabody. CD4+ T cells released more IL3 than CD8+ T cells, while CD8+ T cells produced more TNFα. IFNγ had no difference when released by both T cell subgroups. *p < 0.05 and **p < 0.01 were compared to the controls. T subpopulation groups were the controls. TC target cells. qPCR:a,c,e.ELISA:b,d,f 

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Journal of Hematology & Oncology

ISSN: 1756-8722

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