Fig. 5

a Cell viability results in primary ALL blast cells after 24 h of exposure to PF-0477736 at 100, 500, and 1000 nM. b Cell viability results in normal bone marrow mononuclear cells after 24 h of exposure to PF-0477736 at 100, 500, and 1000 nM. c Survival curves of leukemic mice treated with PF-0477736 and control mice injected with vehicle. PF-0477736 treatment significantly increases the overall survival of mice transplanted with murine lymphoid leukemia (p value =0.0009)