Fig. 3

Overall schema of the study design. Individual dose titration was performed for the next cycle based on the observations from the previous cycle (solid straight arrows). Cohort dose estimation was performed to determine initial doses (broken line arrows): (i) for cohort 2, using all data obtained from cohort 1 until the initiation of cohort 2; (ii) for cohorts 3–5, using only Cycle 1 data of previous subjects. The dose of Cycle 4 was maintained until the completion of decitabine treatment (Cycle 12) (dotted lines)