Table 1 Gene significantly upregulated more than twofold in PTTG1 high MM patients
Probeset IDa | Gene symbol | Fisher’s p valueb | Fold changec [mean (95 % CI)] |
|---|---|---|---|
Regulation Of cell cycle | |||
 213226_at | CCNA2 | 2.20 × 10−31 | 2.32 (1.84–2.80) |
 214710_s_at | CCNB1 | 2.18 × 10−40 | 4.07 (2.61–5.53) |
 202705_at | CCNB2 | 1.98 × 10−41 | 3.54 (1.93–5.14) |
 203213_at | CDK1 | 9.11 × 10−37 | 3.91 (2.44–5.39) |
 1555758_a_at | CDKN3 | 1.63 × 10−40 | 2.90 (1.68–4.13) |
 204170_s_at | CKS2 | 2.02 × 10−35 | 2.88 (2.69–3.07) |
 218350_s_at | GMNN | 1.03 × 10−32 | 2.32 (1.71–2.93) |
 204825_at | MELK | 5.20 × 10−35 | 2.67 (1.88–3.47) |
DNA replication | |||
 206102_at | GINS1 | 6.74 × 10−29 | 2.99 (1.91–4.07) |
 202107_s_at | MCM2 | 1.04 × 10−33 | 2.33 (1.79–2.87) |
 201930_at | MCM6 | 5.41 × 10−20 | 2.03 (1.32–2.74) |
 201202_at | PCNA | 1.74 × 10−22 | 2.36 (1.81–2.91) |
 204127_at | RFC3 | 3.82 × 10−17 | 2.12 (1.27–2.97) |
 209773_s_at | RRM2 | 2.80 × 10−36 | 4.15 (2.38–5.92) |
 1554696_s_at | TYMS | 7.15 × 10−41 | 2.47 (0.95–4.00) |
Response to DNA damage | |||
 205394_at | CHEK1 | 1.33 × 10−36 | 2.74 (1.88–3.61) |
 213007_at | FANCI | 2.04 × 10−24 | 2.25 (1.04–3.47) |
 202503_s_at | KIAA0101 | 1.34 × 10−38 | 3.59 (2.23–4.96) |
 223700_at | MND1 | 9.45 × 10−41 | 2.03 (1.44–2.92) |
 219148_at | PBK | 3.18 × 10−38 | 3.62 (1.60–5.64) |
 205909_at | POLE2 | 5.33 × 10−25 | 2.08 (1.49–2.67) |
 204146_at | RAD51AP1 | 2.74 × 10−26 | 2.41 (1.56–3.26) |
 219258_at | TIPIN | 2.66 × 10−33 | 2.06 (1.70–2.41) |
 204033_at | TRIP13 | 4.71 × 10−38 | 2.45 (1.87–3.04) |
Mitotic spindle and microtubule organisation | |||
 208079_s_at | AURKA | 4.49 × 10−35 | 2.74 (2.22–3.26) |
 204162_at | NDC80 | 1.96 × 10−32 | 3.23 (1.85–4.62) |
 204641_at | NEK2 | 1.24 × 10−29 | 2.84 (1.65–4.03) |
 218039_at | NUSAP1 | 9.20 × 10−37 | 3.47 (1.29–5.66) |
 218009_s_at | PRC1 | 4.37 × 10−31 | 2.54 (1.69–3.39) |
 222077_s_at | RACGAP1 | 5.24 × 10−31 | 3.01 (1.90–4.13) |
 209891_at | SPC25 | 3.04 × 10−40 | 2.84 (2.62–3.06) |
 200783_s_at | STMN1 | 1.27 × 10−34 | 2.33 (1.73–2.94) |
 204822_at | TTK | 1.30 × 10−34 | 2.66 (1.03–4.28) |
 204026_s_at | ZWINT | 4.49 × 10−29 | 3.09 (1.01–5.17) |
Sister chromatid segregation | |||
 202095_s_at | BIRC5 | 8.63 × 10−38 | 2.60 (1.94–3.26) |
 204962_s_at | CENPA | 7.33 × 10−38 | 2.97 (2.14–3.81) |
 231772_x_at | CENPH | 2.98 × 10−32 | 2.12 (1.76–2.47) |
 222848_at | CENPK | 5.40 × 10−31 | 2.90 (1.86–3.94) |
 219555_s_at | CENPN | 1.53 × 10−33 | 2.06 (1.45–2.67) |
 226936_at | CENPW | 2.43 × 10−39 | 2.40 (1.39–3.41) |
 218663_at | NCAPG | 2.21 × 10−34 | 2.61 (1.44–3.79) |
 213599_at | OIP5 | 6.22 × 10−41 | 2.99 (2.39–3.59) |
Ubiquitin ligase activity | |||
 202870_s_at | CDC20 | 1.02 × 10−36 | 2.43 (2.28–2.58) |
 222680_s_at | DTL | 4.43 × 10−29 | 2.88 (1.22–4.55) |
 203362_s_at | MAD2L1 | 1.01 × 10−32 | 3.07 (1.92–4.23) |
 202954_at | UBE2C | 2.48 × 10−37 | 2.20 (1.15–3.24) |
 223229_at | UBE2T | 4.11 × 10−30 | 2.30 (0.82–3.78) |
Chromatin modification | |||
 203358_s_at | EZH2 | 1.21 × 10−24 | 2.41 (1.63–3.20) |
 227212_s_at | PHF19 | 1.18 × 10−29 | 2.38 (1.59–3.17) |
Other | |||
 222958_s_at | DEPDC1 | 2.47 × 10−25 | 2.32 (1.31–3.32) |
 226980_at | DEPDC1B | 2.52 × 10−33 | 2.37 (2.00–2.74) |
 225834_at | FAM72A/FAM72B/FAM72C/FAM72D | 1.10 × 10−29 | 3.31 (1.01–5.62) |
 228069_at | MTFR2 | 1.36 × 10−31 | 2.07 (1.62–2.53) |
 235113_at | PPIL5 | 3.17 × 10−27 | 2.08 (1.53–2.63) |
 229551_x_at | ZNF367 | 1.30 × 10−20 | 2.20 (1.48–2.93) |