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Table 1 Single-agent activity of SMO inhibitor in AML. Micromolar (μM) EC50 values of SMO inhibitors LDE225 (erismodegib) and GDC0449 (vismodegib) in AML cell lines

From: The Hedgehog pathway as targetable vulnerability with 5-azacytidine in myelodysplastic syndrome and acute myeloid leukemia

Cell line

LDE225

GDC0449

EC50 [μM]

EC50 [μM]

MDS-L

15.2

62

TF-1 FLT3-ITD

13.6

UKE-1

11.9

HEL

11.9

83

ML-2

11.0

12

K562

10.3

32

SET-2

9.7

52

THP-1

9.4

41

OCI-AML3

9.0

38

OCI-AML2

6.9

MV4-11

5.4

M07e

5.2

HL-60

4.3

15

TF-1

3.8

45