Table 2 Synergy between 5-azacytidine and erismodegib in AML. Sensitization and synergy between LDE225 (erismodegib) and 5-azacytidine (5-Aza). EC50 values in micromolar (μM) and synergy presented as combination index (CI) values
Cell line | EC50 5-Aza alone [μM] | EC50 5-Aza + LDE225 [μM] | CI | EC50 LDE225 alone [μM] |
|---|---|---|---|---|
TF-1 | 2.7 | 1.8 | 0.55 | 3.8 |
MDS-L | 7.2 | 4.8 | 0.71 | 15.2 |
HL-60 | 1.0 | 0.5 | 0.68 | 4.3 |
MV4-11 | 2.2 | 1.1 | 0.68 | 5.4 |
ML-2 | 1.5 | 1.0 | 0.52 | 11 |
OCI-AML3 | 4.3 | 2.0 | 0.48 | 9 |
THP-1 | 21 | 10 | 0.57 | 10 |