Fig. 4

FRAP assay in BMSCs. a Pre-photobleaching of leukemic BMSCs exposed to ATRA; b 1.5 s post-photobleaching of leukemic BMSCs exposed to ATRA; c 30 min post photobleaching of leukemic BMSCs exposed to ATRA. d–f Leukemic BMSCs without ATRA treatment (d pre-photobleaching of leukemic BMSCs without ATRA treatment; e 1.5 s post-photobleaching of leukemic BMSCs without ATRA treatment; f 30 min post photobleaching of leukemic BMSCs without ATRA treatment). g Effects of ATRA on fluorescence redistribution in leukemic BMSCs. h Effects of ATRA on GJIC in leukemic BMSCs. Arrow symbols photobleached cells. *p < 0.01 vs. leukemic BMSCs. Images were taken under a laser confocal microscope at ×400 magnification