Fig. 1
From: The roles of stem cell memory T cells in hematological malignancies
Schematic model for T cell differentiation. Upon activation, naive T cells differentiate into various memory and effector cells. Self-renewal capacity, multipotency, and proliferation potential decrease upon differentiation. The expression of CD45R0, CCR7, CD28, and CD95 markers changes during T cell differentiation from TN to TTE. The minimum set of canonical markers can be used to identify the five major subsets of T cells. T N naive T cell, T SCM stem cell memory T cell, T CM central memory T cell, T EM effector memory T cell, T TE terminal effector T cell