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Table 1 Comparison of treatment responses of patients with low (Q1–3) vs. high (Q4) MEF2C expression

From: High expression of myocyte enhancer factor 2C (MEF2C) is associated with adverse-risk features and poor outcome in pediatric acute myeloid leukemia: a report from the Children’s Oncology Group

Outcome at 5 years

Relative MEF2C expression

P value*

Low (Q1–3)

High (Q4)

Hazard ratioa

95 % confidence interval

All patients

n = 563

n = 188

   

 OS

67 ± 4 %

55 ± 8 %

1.385

1.07–1.80

0.014

 EFS

54 ± 4 %

38 ± 7 %

1.510

1.21–1.88

<0.001

 RR

35 ± 5 %

53 ± 9 %

1.813

1.36–2.42

<0.001

Low-risk patients

n = 255

n = 29

   

 OS

81 ± 5 %

76 ± 20 %

1.433

0.43–4.82

0.561

 EFS

69 ± 6 %

51 ± 20 %

1.597

0.90–2.82

0.104

 RR

23 ± 6 %

49 ± 20 %

2.290

1.26–4.17

0.011

Standard-risk patients

n = 230

n = 123

   

 OS

55 ± 7 %

55 ± 9 %

0.992

0.71–1.38

0.961

 EFS

42 ± 7 %

38 ± 9 %

1.143

0.86–1.52

0.356

 RR

49 ± 8 %

55 ± 11 %

1.270

0.88–1.83

0.201

High-risk patients

n = 69

n = 30

   

 OS

52 ± 12 %

37 ± 10 %

1.452

0.81–2.59

0.204

 EFS

31 ± 11 %

29 ± 17 %

1.155

0.70–1.92

0.576

 RR

46 ± 16 %

47 ± 27 %

1.381

0.59–3.22

0.446

  1. *Log-rank P value
  2. aEstimates from Weibull parametric models