Fig. 1
From: ABT-199 (venetoclax) and BCL-2 inhibitors in clinical development
Structures of BCL-2 family proteins. According to the BH domains, the BCL-2 family proteins can be categorized into three subsets. BH4-containing BCL-2 and related BCL-XL, BCL-w, MCL-1, A1(BFL-1), and Boo are anti-apoptotic proteins. The remaining two subsets (BAX and Bik subgroups) do not have a BH4 domain and are pro-apoptotic proteins