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Table 2 Clinical trials of venetoclax/ABT-199 in combination regimens

From: ABT-199 (venetoclax) and BCL-2 inhibitors in clinical development

Clinical trials

Regimens

Diseases

Responses

References

Phase Ib

V + R

R/R CLL

ORR—88 %

86, 87

CR/CRi—32 %

PR—56 %

Phase I

V + BR

R/R NHL

ORR—61.5 %

89

Phase Ib

V + BR

R/R CLL

Not reported

90

Untreated CLL

Phase Ib

V + O

R/R CLL

Not reported

91

Untreated CLL

  1. R/R relapsed/refractory, ORR overall response rate, CLL chronic lymphoid leukemia, NHL non-Hodgkin’s lymphoma, AML acute myeloid leukemia. For regimens: V venetoclax, R rituximab, B bendamustine, O obinutuzumab