Fig. 1From: MicroRNA-26a suppresses epithelial-mesenchymal transition in human hepatocellular carcinoma by repressing enhancer of zeste homolog 2Down-regulation of miR-26a induced EMT in hepatoma cells in vitro. a Morphologic changes consistent with EMT (spindle-shaped cells with loss of polarity and increased intercellular separation) were observed in the HCCLM3-anti-miR-26a cells compared to control cells; HepG2 cells did not show morphological changes. b Cell migration through a Transwell chamber was compared between hepatoma cells transfected with miR-26a and control. The number of migrated cells was evaluated by counting 10 random fields at ×100 magnification. Western blot (c) and immunofluorescence assays (d) showed that down-regulation of miR-26a resulted in down-regulation of E-cadherin and up-regulation of N-cadherin and vimentinBack to article page