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Fig. 2 | Journal of Hematology & Oncology

Fig. 2

From: MicroRNA-26a suppresses epithelial-mesenchymal transition in human hepatocellular carcinoma by repressing enhancer of zeste homolog 2

Fig. 2

EZH2 played a critical role in miR-26a modulating EMT process. a Western blot assay showed that miR-26a down-regulated EZH2 expression and up-regulated E-cadherin expression. b Diagram of the putative binding sequence of miR-26a in the 3′-UTR containing reporter constructs of EZH2 is shown. c Luciferase reporter assays showed that miR-26a significantly decreased the luciferase activity of wild-type EZH2 but not mutant EZH2. NC, the mock of precursor miRNA, *P < 0.05 compared with control. d EZH2 siRNA transfection in HCC cells eliminated the difference in E-cadherin miR-26 overexpression and down-regulation

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