Fig. 2
Establishment of the G1XP B cell lymphoma model. a Kaplan-Meier survival curve: percent survival of wt controls (n = 37) and Cγ1CreX c P c mice (n = 51) vs age in days is shown. b Southern Blot analysis of second cohort of Cγ1CreX c P c mice for JH rearrangements. G1XP lymphoma genomic DNA was employed for EcoRI digestion and hybridized with the JH4 probe. Germline (GL) bands are indicated (arrow heads). MLN stands for mesenteric lymph node. c H&E analysis of G1XP lymphomas. Left: a high level of apoptotic cells (red arrows) (objective ×40); Right: diffusely enlarged nuclei (red arrow, bottom) and salient nucleoli (red arrow, top) (objective ×63). Scale bars 50 μm