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Fig. 3 | Journal of Hematology & Oncology

Fig. 3

From: Combined deletion of Xrcc4 and Trp53 in mouse germinal center B cells leads to novel B cell lymphomas with clonal heterogeneity

Fig. 3

Analysis of CTX junctions identifies known and novel translocation partners. a A Circos plot depicts all CTXs involving Igh, Igκ, and Igλ loci. Individual chromosomes are shown as color-coded bars with specific banding patterns. The region on chr12 (in green) (114,480,000–117,249,000) is zoomed in ×400 including the Igh locus while the region on chr15 (in blue) (61,800,000–62,083,000) is zoomed in ×1600 including c-myc and Pvt1 loci. All Igh CTXs involving S or C regions are translocated to c-myc or Pvt1 locus shown as a cluster of blue lines. All other Ig CTXs involving V gene segments are translocated to various chromosomes shown as different color-coded lines. b The view within the IGV browser shows all the CTX breakpoints occurring upstream of or within c-myc 1st exon. c The location of Pvt1 translocations shown in the IGV browser. d Analysis of junction sequences of the Igh-Pvt1 translocation. Sequences from NGS are aligned with genomic sequences of mm9 with chr15 sequence in black and chr12 sequence in blue. Micro-homology at the junctions is in red and underlined

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