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Fig. 6 | Journal of Hematology & Oncology

Fig. 6

From: Combined deletion of Xrcc4 and Trp53 in mouse germinal center B cells leads to novel B cell lymphomas with clonal heterogeneity

Fig. 6

G1XP lymphomas harbor ongoing DNA damage. a FACS analysis of a GC B cell marker, PNA (left panel) and γ-H2AX foci staining (right panel) for G1XP lymphomas (n = 3 per group). b Wt splenocytes were isolated from immunized mice and stained for GC B cell markers, B220 and PNA. The level of γ-H2AX foci staining was shown for naïve B cells (B220+PNAlow) and GC B cells (B220+PNAhigh). Representative FACS plots are shown from three independent experiments using independent tumor samples

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