Fig. 7

G1XP lymphomas harbor a high level of clonal heterogeneity. a Quantification of c-myc translocations in G1XP lymphoma samples (n = 3 independent tumor samples) analyzed by metaphase FISH. We subdivide the configuration of FISH signals into three categories: Intact: green and red probes co-localized; G only: green probe only (3′ c-myc), R only: red probe only (5′ c-myc). The frequency of different configurations of FISH signals was shown from one representative sample, and at least 150 metaphases were analyzed in total for each sample. b Top: Diagram of c-myc FISH probes. Bottom: Representative c-myc translocations showing different configurations of FISH signals. Numbers in parenthesis indicate the number of FISH signals for each category. Intact: yellow arrows; G only: green arrows; R only: red arrows