Table 2 Top regulated pathways in the list of upregulated genes in HR-MDS mice
Functional pathway KEGG database | n | Up P value | Upregulated genesa |
|---|---|---|---|
Genetic information processing Proteasome | 7 | 4.3E-04 | PSMD14, PSMD12, PSMC4, PSMA5, PSMD2, POMP, PSME4 |
PSMD14, PSMD12, PSMC4, PSMA5, PSMD2, PSME4 : PSM family (proteasome 26S subunit) | |||
POMP: proteasome maturation protein | |||
Energy Metabolism Oxidative phosphorylation | 10 | 2.0E-03 | NDUFB3, NDUFV2, ATP5C1, COX4I2, COX4I1, VDAC2, VDAC3, ATP5J, SLC25A4, PPID |
NDUFB3, NDUFV2: NADH Ubiquinone oxido reductase | |||
ATP5C1, ATP5J: one of the subunits of mitochondria APTase | |||
VDAC2, VDAC3: voltage dependent anion channel. | |||
COX4I2, COX4I1cytochrome c oxidase subunit 4 | |||
SLC25A4: SOLUTE CARRIER FAMILY 25 mitochondrial ADP/ATP translocator | |||
PPID: peptidylprolyl isomerase D | |||
Lipid metabolism Ether lipid metabolism | 4 | 3.7E-02 | PAFAH1B3, AGPAT4, PPAP2A, CHPT1 |
PAFAH1B3: platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 | |||
AGPAT4: 1-acylglycerol-3-phosphate O-acyltransferase 4 | |||
PPAP2A: Phosphatidic Acid Phosphatase 2a | |||
CHPT1: choline phosphor transferase 1 | |||
Lipid metabolism Glycosphingolipid biosynthesis | 3 | 3.9E-02 | SLC33A1, HEXB, GLB1 |
SLC33A1: solute carrier family 33 (acetyl-CoA transporter) | |||
HEXB: hexosaminidase B (beta polypeptide) | |||
GLB1 : Galactosidase, beta 1 | |||
Cellular processes Cell cycle | 7 | 5.4E-02 | MAD2L1, CCNH, SKP2, MDM2, CHEK2, CDC25A, BUB3 |
MAD2L1, mitotic spindle assembly checkpoint (interacts with BUB1) | |||
CCNH: cyclin H; SKP2 : S-phase kinase-associated protein 2 | |||
MDM2: mouse double minute 2 homolog (E3 ubiquitin-protein ligase); CHEK2: checkpoint | |||
BUB3: budding uninhibited by benzimidazole (checkpoint protein ) |