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Table 2 Top regulated pathways in the list of upregulated genes in HR-MDS mice

From: GEP analysis validates high risk MDS and acute myeloid leukemia post MDS mice models and highlights novel dysregulated pathways

Functional pathway KEGG database n Up P value Upregulated genesa
Genetic information processing Proteasome 7 4.3E-04 PSMD14, PSMD12, PSMC4, PSMA5, PSMD2, POMP, PSME4
PSMD14, PSMD12, PSMC4, PSMA5, PSMD2, PSME4 : PSM family (proteasome 26S subunit)
POMP: proteasome maturation protein
Energy Metabolism Oxidative phosphorylation 10 2.0E-03 NDUFB3, NDUFV2, ATP5C1, COX4I2, COX4I1, VDAC2, VDAC3, ATP5J, SLC25A4, PPID
NDUFB3, NDUFV2: NADH Ubiquinone oxido reductase
ATP5C1, ATP5J: one of the subunits of mitochondria APTase
VDAC2, VDAC3: voltage dependent anion channel.
COX4I2, COX4I1cytochrome c oxidase subunit 4
SLC25A4: SOLUTE CARRIER FAMILY 25 mitochondrial ADP/ATP translocator
PPID: peptidylprolyl isomerase D
Lipid metabolism
Ether lipid metabolism
4 3.7E-02 PAFAH1B3, AGPAT4, PPAP2A, CHPT1
PAFAH1B3: platelet-activating factor acetylhydrolase 1b, catalytic subunit 3
AGPAT4: 1-acylglycerol-3-phosphate O-acyltransferase 4
PPAP2A: Phosphatidic Acid Phosphatase 2a
CHPT1: choline phosphor transferase 1
Lipid metabolism Glycosphingolipid biosynthesis 3 3.9E-02 SLC33A1, HEXB, GLB1
SLC33A1: solute carrier family 33 (acetyl-CoA transporter)
HEXB: hexosaminidase B (beta polypeptide)
GLB1 : Galactosidase, beta 1
Cellular processes
Cell cycle
7 5.4E-02 MAD2L1, CCNH, SKP2, MDM2, CHEK2, CDC25A, BUB3
MAD2L1, mitotic spindle assembly checkpoint (interacts with BUB1)
CCNH: cyclin H; SKP2 : S-phase kinase-associated protein 2
MDM2: mouse double minute 2 homolog (E3 ubiquitin-protein ligase); CHEK2: checkpoint
BUB3: budding uninhibited by benzimidazole (checkpoint protein )
  1. aGene card nomenclature