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Table 3 Top regulated pathways in the list of downregulated genes in HR-MDS mice

From: GEP analysis validates high risk MDS and acute myeloid leukemia post MDS mice models and highlights novel dysregulated pathways

Functional pathway KEGG database

n

Down P value

Downregulated genesa

Cellular processes Inhibition of Apoptosis

5

1.2E-2

NAIP6, NAIP5, NLRC4, MAPK9, TNFAIP3

NAIP6; NAIP5: NLR family, apoptosis inhibitory protein 6; NLRC4: NLR family CARD domain-containing protein 4; MAPK9: Mitogen activated kinase 9; TNFAIP3: Tumor necrosis factor, alpha-induced protein 3

Environmental adaptation Circadian rhythm

3

1.4E-2

NR1D1, PER1, CLOCK

NR1D1: nuclear receptor subfamily 1, group D, member 1

PER1: period circadian clock 1

CLOCK: circadian locomotor output cycles kaput

Signal transduction Phosphatidylinositol signaling system

5

2.2E-2

PIK3C2A, PIK3C2B, PIP4K2A, PTEN, ITPR1

PIK3C2A: phosphatidylinositol-4-phosphate 3-kinase

PIP4K2A: phosphatidylinositol-5-phosphate 4-kinase, type II,

PTEN: phosphatase and tensin homolog

ITPR1: inositol 1,4,5-trisphosphate receptor type 1

Human diseases

Type II diabetes mellitus

4

3.2E-2

IRS2, MAPK9, CACNA1E, SOCS4

IRS2: insulin receptor substrate 2; MAPK9: mitogen activated kinase 9

CACNA1E: calcium channel, voltage-dependent, R type, alpha 1E subunit

SOCS4: suppressor of cytokine signaling 4

Human diseases

Primary immunodeficiency

3

9.3E-2

CD19, RFX5, CD40

CD19: antigen receptor of B lymphocytes; RFX5: regulatory factor X; CD40: TNF receptor superfamily member 5