Functional pathway KEGG database | n | Down P value | Downregulated genesa |
---|---|---|---|
Cellular processes Inhibition of Apoptosis | 5 | 1.2E-2 | NAIP6, NAIP5, NLRC4, MAPK9, TNFAIP3 |
NAIP6; NAIP5: NLR family, apoptosis inhibitory protein 6; NLRC4: NLR family CARD domain-containing protein 4; MAPK9: Mitogen activated kinase 9; TNFAIP3: Tumor necrosis factor, alpha-induced protein 3 | |||
Environmental adaptation Circadian rhythm | 3 | 1.4E-2 | NR1D1, PER1, CLOCK |
NR1D1: nuclear receptor subfamily 1, group D, member 1 | |||
PER1: period circadian clock 1 | |||
CLOCK: circadian locomotor output cycles kaput | |||
Signal transduction Phosphatidylinositol signaling system | 5 | 2.2E-2 | PIK3C2A, PIK3C2B, PIP4K2A, PTEN, ITPR1 |
PIK3C2A: phosphatidylinositol-4-phosphate 3-kinase | |||
PIP4K2A: phosphatidylinositol-5-phosphate 4-kinase, type II, | |||
PTEN: phosphatase and tensin homolog | |||
ITPR1: inositol 1,4,5-trisphosphate receptor type 1 | |||
Human diseases Type II diabetes mellitus | 4 | 3.2E-2 | IRS2, MAPK9, CACNA1E, SOCS4 |
IRS2: insulin receptor substrate 2; MAPK9: mitogen activated kinase 9 | |||
CACNA1E: calcium channel, voltage-dependent, R type, alpha 1E subunit | |||
SOCS4: suppressor of cytokine signaling 4 | |||
Human diseases Primary immunodeficiency | 3 | 9.3E-2 | CD19, RFX5, CD40 |
CD19: antigen receptor of B lymphocytes; RFX5: regulatory factor X; CD40: TNF receptor superfamily member 5 |