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Fig. 3 | Journal of Hematology & Oncology

Fig. 3

From: CCR9 in cancer: oncogenic role and therapeutic targeting

Fig. 3

Diagram summarizing the reviewed mechanisms by which CCR9 induces different aspects of tumor metastasis. a The interaction of CCL25 and CCR9 can induce tumor metastasis via the RAS-MAPK-MMP pathway, the RhoA-Rock-MLC pathway, and ezrin signaling. b CCR9-high-expressing tumor cells are targeted to the small intestine and gastrointestinal tract by CCL25/CCR9 signaling. The solid arrows indicate that these signaling pathways have confirmed; the dashed arrows show that these signaling pathways need to be further validation

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