|
Drug related/non-drug related, n
|
Treatment cycle
|
|---|
|
Any (n = 32)
|
1 (n = 32)
|
2 (n = 28)
|
3 (n = 25)
|
4 (n = 21)
|
5 (n = 14)
|
6 (n = 11)
|
>6 (n = 5)
|
|---|
|
Any grade AEs reported in > 20 % of patients with best response of SD
|
|
Nausea
|
22/2
|
18/2
|
6/0
|
5/0
|
5/1
|
5/0
|
0/0
|
1/0
|
|
Asthenia/fatigue
|
19/1
|
13/0
|
6/0
|
4/0
|
4/0
|
3/1
|
2/1
|
1/0
|
|
Infections SOC
|
6/11
|
4/6
|
1/3
|
1/2
|
0/5
|
1/1
|
1/2
|
1/2
|
|
Dysgeusia
|
14/0
|
8/0
|
7/0
|
1/0
|
2/0
|
0/0
|
0/0
|
0/0
|
|
Vomiting
|
12/1
|
5/0
|
4/1
|
4/0
|
3/1
|
4/0
|
0/0
|
1/0
|
|
Diarrhea
|
7/5
|
5/1
|
4/2
|
1/0
|
1/0
|
0/1
|
0/1
|
1/0
|
|
Constipation
|
5/6
|
3/3
|
0/0
|
2/0
|
0/0
|
1/1
|
0/0
|
0/1
|
|
Anorexia
|
11/0
|
6/0
|
3/0
|
3/0
|
1/0
|
2/0
|
0/0
|
1/0
|
|
Thrombocytopenia
|
10/0
|
6/0
|
2/0
|
3/0
|
2/0
|
2/0
|
2/0
|
0/0
|
|
Pyrexia
|
7/1
|
1/1
|
1/0
|
0/1
|
2/1
|
1/1
|
1/1
|
1/1
|
|
Neutropenia
|
7/0
|
4/0
|
4/0
|
3/0
|
2/0
|
1/0
|
1/0
|
2/0
|
|
Anemia
|
6/1
|
1/1
|
2/0
|
1/0
|
1/0
|
0/0
|
1/0
|
2/0
|
|
Grade ≥ 3 AEs reported in > 1 patients with best response of SD
|
|
Neutropenia
|
7/0
|
4/0
|
3/0
|
2/0
|
1/0
|
1/0
|
0/0
|
2/0
|
|
Thrombocytopenia
|
6/0
|
3/0
|
1/0
|
1/0
|
1/0
|
1/0
|
1/0
|
0/0
|
|
Infections SOC
|
2/3
|
1/2
|
0/0
|
0/0
|
0/0
|
0/0
|
1/0
|
0/2
|
|
Anemia
|
3/0
|
0/0
|
1/0
|
0/0
|
0/0
|
0/0
|
1/0
|
1/0
|
- Patients who experienced drug-related events may have also experienced non-drug-related events
-
SOC system organ class
