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Table 1 Hazard ratio (HR) for clinical factors in the overall survival of lower-grade glioma

From: Systematic analysis of overall survival and interactions between tumor mutations and drug treatment

Factors

N [n death]

HR

Univariate

Multivariate

95 % CI

p

HR

95 % CI

p

Age

261

1.07

1.05–1.09

5e−10

1.07

1.05–1.09

6e−9

Gender

 

 Female

117 [30]

1

     

 Male

144 [33]

0.88

0.54–1.45

0.620

   

Temozolomide

 No

41 [24]

1

     

 Yes

220 [39]

0.80

0.47–1.35

0.398

   

R132H in IDH1

 Undetected

166 [45]

1

     

 Detected

95 [18]

0.74

0.43–1.29

0.292

   

Interaction drug-mutation

 Absent

181 [57]

1

  

1

  

 Present

80 [6]

0.35

0.15–0.83

0.016

0.09

0.01–0.58

0.012

Histology

 Astrocytoma

107 [27]

1

     

 Oligoastrocytoma/oligodendroglioma

154 [36]

0.67

0.40–1.10

0.112

   

Tumor grade

 Grade II

77 [18]

1

  

1

  

 Grade III

184 [45]

2.06

1.18–3.61

0.011

1.52

0.85–2.71

0.159

Laterality

 N.A.

1

      

 Left

131 [28]

1

     

 Midline

5 [1]

0.34

0.04–2.64

0.304

   

 Right

123 [33]

0.82

0.49–1.37

0.443

   

Tumor site

 N.A./other

3

   

1

  

 Supratentorial, frontal lobe

160 [36]

1

     

 Supratentorial, occipital lobe

5 [1]

0.71

0.10–5.20

0.736

   

 Supratentorial, parietal lobe

23 [4]

0.84

0.30–2.38

0.748

   

 Supratentorial, temporal lobe

70 [21]

1.86

1.08–3.22

0.026

1.22

0.70–2.11

0.481

Symptoms at diagnosis

 

 N.A./other

19

      

 Headaches

62 [18]

1

     

 Mental status changes

22 [8]

1.84

0.80–4.27

0.153

   

 Motor/movement changes

22 [6]

1.20

0.47–3.06

0.698

   

 Seizures

119 [23]

0.58

0.31–1.08

0.087

   

 Sensory changes

11 [2]

1.07

0.24–4.66

0.929

   

 Visual changes

6 [2]

0.69

0.16–2.98

0.617