From: Systematic analysis of overall survival and interactions between tumor mutations and drug treatment
Factors | N [n death] | HR | Univariate | Multivariate | |||
---|---|---|---|---|---|---|---|
95 % CI | p | HR | 95 % CI | p | |||
Age | 261 | 1.07 | 1.05–1.09 | 5e−10 | 1.07 | 1.05–1.09 | 6e−9 |
Gender | |||||||
Female | 117 [30] | 1 | |||||
Male | 144 [33] | 0.88 | 0.54–1.45 | 0.620 | |||
Temozolomide | |||||||
No | 41 [24] | 1 | |||||
Yes | 220 [39] | 0.80 | 0.47–1.35 | 0.398 | |||
R132H in IDH1 | |||||||
Undetected | 166 [45] | 1 | |||||
Detected | 95 [18] | 0.74 | 0.43–1.29 | 0.292 | |||
Interaction drug-mutation | |||||||
Absent | 181 [57] | 1 | 1 | ||||
Present | 80 [6] | 0.35 | 0.15–0.83 | 0.016 | 0.09 | 0.01–0.58 | 0.012 |
Histology | |||||||
Astrocytoma | 107 [27] | 1 | |||||
Oligoastrocytoma/oligodendroglioma | 154 [36] | 0.67 | 0.40–1.10 | 0.112 | |||
Tumor grade | |||||||
Grade II | 77 [18] | 1 | 1 | ||||
Grade III | 184 [45] | 2.06 | 1.18–3.61 | 0.011 | 1.52 | 0.85–2.71 | 0.159 |
Laterality | |||||||
N.A. | 1 | ||||||
Left | 131 [28] | 1 | |||||
Midline | 5 [1] | 0.34 | 0.04–2.64 | 0.304 | |||
Right | 123 [33] | 0.82 | 0.49–1.37 | 0.443 | |||
Tumor site | |||||||
N.A./other | 3 | 1 | |||||
Supratentorial, frontal lobe | 160 [36] | 1 | |||||
Supratentorial, occipital lobe | 5 [1] | 0.71 | 0.10–5.20 | 0.736 | |||
Supratentorial, parietal lobe | 23 [4] | 0.84 | 0.30–2.38 | 0.748 | |||
Supratentorial, temporal lobe | 70 [21] | 1.86 | 1.08–3.22 | 0.026 | 1.22 | 0.70–2.11 | 0.481 |
Symptoms at diagnosis | |||||||
N.A./other | 19 | ||||||
Headaches | 62 [18] | 1 | |||||
Mental status changes | 22 [8] | 1.84 | 0.80–4.27 | 0.153 | |||
Motor/movement changes | 22 [6] | 1.20 | 0.47–3.06 | 0.698 | |||
Seizures | 119 [23] | 0.58 | 0.31–1.08 | 0.087 | |||
Sensory changes | 11 [2] | 1.07 | 0.24–4.66 | 0.929 | |||
Visual changes | 6 [2] | 0.69 | 0.16–2.98 | 0.617 |