Fig. 6
From: Pharmacological inhibition of LSD1 for the treatment of MLL-rearranged leukemia
Microarray results of LSD1 inhibition in MV4-11 cells. Upon treatment with compound 1 (100 nM), GSEA plots showed significant upregulation of the gene sets of a hematopoietic cell lineage (HSA04640), b leukocyte differentiation (GO:0002521), and c hematopoietic or lymphoid organ development (GO:0048534), as well as d the pro-apoptotic gene set of regulation of programmed cell death (GO:0043067). The right panels in a–d are heat maps showing expression levels of selected genes in the leading edges of the GSEA plots