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Table 5 Best overall response to ASP3026 in the dose-expansion cohort

From: First-in-human, open-label dose-escalation and dose-expansion study of the safety, pharmacokinetics, and antitumor effects of an oral ALK inhibitor ASP3026 in patients with advanced solid tumors

Parameter

Expansion cohort ASP3026 525 mg (n = 16)

Best overall responsea, n (%)

 

 Complete response

0

 Partial response

8 (50)

 Stable disease

7 (44)

 Progressive disease

0

 Unable to evaluate

1 (6)

Objective response (complete response + partial response)

 

n (%)

8 (50)

 95 % CIb

25–75 %

  1. CI confidence interval
  2. aBased on RECIST guidelines (v1.1) and International Working Group revised response criteria
  3. bExact CI obtained using Clopper–Pearson method