Table 1 Characteristics of 135 patients with advanced-stage classic Hodgkin lymphoma and 221 healthy controls

Sex, no. (%)

  Male

67

(49.6)

104 (47.1)

NS

  Female

68

(50.4)

117 (52.9)

NS

Age at diagnosis, mean (range)

34

(15–69)

35 (25–55)

NS

Disease subtype, no. (%)

  Nodular sclerosing

108

(80.0)

  Mixed-cellularity

14

(10.4)

  Lymphocyte-rich

9

(6.7)

  Lymphocyte-depleted

4

(2.9)

Albumin, g/dl, mean (range)

3.8

(2.2–5.1)

Hemoglobin, g/dl, mean (range)

13.0

(8.3–14.2)

Lymphocytes, ×10³/μL, mean (range)

1.75

(0.3–4.9)

Neutrophils, ×10³/μL, mean (range)

8.55

(2.1–35.8)

Bulky mass, no. (%)

55

(40.7)

“B” symptoms, no. (%)

73

(54.1)

Extranodal extension, no. (%)

42

(31.1)

IPS score ≥ 4 (unfavorable in advanced stages)

39

(28.9)

Ann Arbor stage 1–2a, no. (%)

0

(0)

  Stage 2b, no. (%)

57

(42.2)

  Stage 3, no. (%)

45

(33.3)

  Stage 4, no. (%)

33

(24.5)