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Fig. 1 | Journal of Hematology & Oncology

Fig. 1

From: Anti-proliferative effects of T cells expressing a ligand-based chimeric antigen receptor against CD116 on CD34+ cells of juvenile myelomonocytic leukemia

Fig. 1

Generation of T cells modified to express GMR CAR with piggyBac transposons. a A CAR targeting GM-CSF receptor (GMR CAR) was constructed by replacing the anti-CD19 scFv portion of a piggyBac transposon plasmid encoding CD19 CAR (pIRII- CAR.CD19) with full-length GM-CSF. b Surface expression of GMR CAR in transgenic T cells expanded by stimulation with anti-CD3/CD28 mAbs

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Journal of Hematology & Oncology

ISSN: 1756-8722

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