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Fig. 1 | Journal of Hematology & Oncology

Fig. 1

From: Discovery and characterization of a novel CCND1/MRCK gene fusion in mantle cell lymphoma

Fig. 1

Identification of the novel CCND1/MRCK fusion gene in mantle cell lymphoma. a Western blot analysis confirms cyclin D1 protein expression in three MCL cell lines but not in the normal B cell line RPMI 1788. b PCR products derived from 3′RACE of RNA isolated from RPMI-1788, Jeko-1, Granta-519, and SP-53 cell lines. c A partial sequence shows the junction between the CCND1 and MRCK sequences after blunt-end cloning and sequencing. CCND1 sequence is in red, MRCK is in blue, the canonical poly(A) signal is in green, and the poly(A) tail is in black. d Schematic representation of the t(11;14) translocation as well as the second translocation of CCND1 and MRCK to create the fusion gene

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