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Fig. 4 | Journal of Hematology & Oncology

Fig. 4

From: Rheb1 promotes tumor progression through mTORC1 in MLL-AF9-initiated murine acute myeloid leukemia

Fig. 4

Rheb1 deletion arrests cell cycle progression and increases the apoptosis of AML cells. a Upregulated (left) and downregulated (right) GO terms of differentially expressed genes in Rheb1 Δ/Δ GFP+ cells vs. the WT control. b Enrichment of the cell cycle process. NES (normalized enrichment score) and P values are indicated in each plot. c, d The cell cycle status of GFP+ (c) and K+G cells (d), n = 4. e, f GFP+ cells (e) and K+G cells (f) were sorted, and their RNAs were isolated for indicated gene analysis using RT-PCR. The data represent the mean numbers ± SEM. g, h The apoptosis status of GFP+ (g) and K+G cells (h), n = 4. i, j GFP+ cells (i) and K+G cells (j) were sorted, and RNAs were isolated and analyzed using RT-PCR for the indicated genes. The data represent the mean numbers ± SEM. *P < 0.05; **P < 0.01; ***P < 0.001

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