Skip to main content

Table 2 Variables considered for best donor selection in unmanipulated haplo-SCT with ATG or TCR haplo-SCT with PT/Cy

From: How do we choose the best donor for T-cell-replete, HLA-haploidentical transplantation?

Variables Unmanipulated haplo-SCT with ATG Ref TCR haplo-SCT with PT/Cy Ref
DSA DSA was associated with primary graft failure, including GR and PGF. [12] DSA was associated with an increased risk of graft failure. [93]
Donor age Young donor age (<30) was associated with decreased 2–4 acute GVHD, NRM, and superior survival. [10] No effect of donor age on clinical outcomes was found. [59]
Donor gender F-M (versus others) correlated with higher incidence of 2–4 acute GVHD. [10, 14] Male donors were associated with less NRM and better survival. [36, 102]
NK alloreactivity KIR-ligand mismatch was associated with inferior survival. [23] A survival benefit associated with donor-recipient mismatches of inhibitory KIR and KIR haplotype B donors. [59]
NIMA mismatch NIMA-mismatched was associated with a lower incidence of acute GVHD in unmanipulated haplo-SCT. [10]  
Type of donor Children Children donors were associated with less acute GVHD than sibling donors. [10]  
Mather Maternal donors were associated with more acute GVHD, chronic GVHD, and NRM.  
Older sister Older sister donors were inferior to father donors in NRM and survival.  
Father Father donors were associated with less acute GVHD, less NRM, and better survival than mother donors.  
  1. Haplo-SCT haploidentical stem cell transplantation, ATG anti-thymocyte globulin, TCR T-cell replete, PT/Cy posttransplant cyclophosphamide, Ref reference, DSA donor-specific anti-human leukocyte antibody, GR graft rejection, PGF poor graft function, NK natural killer, KIR inhibitory killer cell immunoglobulin-like receptor, NIMA non-inherited maternal antigen, GVHD graft-versus-host disease, NRM non-relapse mortality, F female, M male
  2. – indicates no data available