How do we choose the best donor for T-cell-replete, HLA-haploidentical transplantation?

Table 2 Variables considered for best donor selection in unmanipulated haplo-SCT with ATG or TCR haplo-SCT with PT/Cy

Variables		Unmanipulated haplo-SCT with ATG	Ref	TCR haplo-SCT with PT/Cy	Ref
DSA		DSA was associated with primary graft failure, including GR and PGF.	[12]	DSA was associated with an increased risk of graft failure.	[93]
Donor age		Young donor age (<30) was associated with decreased 2–4 acute GVHD, NRM, and superior survival.	[10]	No effect of donor age on clinical outcomes was found.	[59]
Donor gender		F-M (versus others) correlated with higher incidence of 2–4 acute GVHD.	[10, 14]	Male donors were associated with less NRM and better survival.	[36, 102]
NK alloreactivity		KIR-ligand mismatch was associated with inferior survival.	[23]	A survival benefit associated with donor-recipient mismatches of inhibitory KIR and KIR haplotype B donors.	[59]
NIMA mismatch		NIMA-mismatched was associated with a lower incidence of acute GVHD in unmanipulated haplo-SCT.	[10]	–
Type of donor	Children	Children donors were associated with less acute GVHD than sibling donors.	[10]	–
	Mather	Maternal donors were associated with more acute GVHD, chronic GVHD, and NRM.		–
	Older sister	Older sister donors were inferior to father donors in NRM and survival.		–
	Father	Father donors were associated with less acute GVHD, less NRM, and better survival than mother donors.		–

Haplo-SCT haploidentical stem cell transplantation, ATG anti-thymocyte globulin, TCR T-cell replete, PT/Cy posttransplant cyclophosphamide, Ref reference, DSA donor-specific anti-human leukocyte antibody, GR graft rejection, PGF poor graft function, NK natural killer, KIR inhibitory killer cell immunoglobulin-like receptor, NIMA non-inherited maternal antigen, GVHD graft-versus-host disease, NRM non-relapse mortality, F female, M male
– indicates no data available

ISSN: 1756-8722