Fig. 1
From: Third-generation inhibitors targeting EGFR T790M mutation in advanced non-small cell lung cancer
Common mutations of the epidermal growth factor receptor (EGFR) that are targets for tyrosine kinase inhibitors. Exons 18 to 21 of EGFR gene are common sites for mutations. The most common mutations that are targets of EGFR TKIs are shown. As an example, three mutation-harboring lung cancer cell lines commonly used to characterize EGFR TKIs are also shown. Del19: exon 19 deletion