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Fig. 2 | Journal of Hematology & Oncology

Fig. 2

From: Lung tumor exosomes induce a pro-inflammatory phenotype in mesenchymal stem cells via NFκB-TLR signaling pathway

Fig. 2

A549 cells derived exosomes significantly stimulate inflammatory cytokines production in MSCs. a Cytokine secretion profile of MSCs and exosomes-treated MSCs. MSCs were incubated with 200ug/ml exosomes for 24 h. b, c The mRNA level and protein level of IL-6, IL-8, and MCP-1 at different time points across a concentration gradient of exosomes (0, 100, 200, 400 μg/ml). d The mRNA expression changes of IL-6, IL-8 and MCP-1of MSCs treated with exosomes-depleted A549 cells culture medium (*P < 0.05, **P < 0.01, ***P < 0.001)

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Journal of Hematology & Oncology

ISSN: 1756-8722

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