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Table 1 Gene lists of human toll-like receptor signaling pathway and data for 3D profile

From: Lung tumor exosomes induce a pro-inflammatory phenotype in mesenchymal stem cells via NFκB-TLR signaling pathway

3D profile gene data A B C D E F G H
1 BTK ECSIT IKBKB IRF3 MYD88 RELA TLR3 ACTB
0.64 0.86 0.88 0.84 1.63 1.17 1.39 1.14
2 CASP8 EIF2AK2 IL10 JUN NFKB1 RIPK2 TLR4 B2M
0.86 1.16 0.41 0.75 1.77 1.06 0.74 1.16
3 CCL2 ELK1 IL12A LTA NFKB2 SARM1 TLR5 GAPDH
13.80 0.85 1.35 0.91 0.41 0.81 1.71 0.87
4 CD14 FADD IL1A LY86 NFKBIA SIGIRR TLR6 HPRT1
1.00 0.91 0.60 0.82 3.01 1.19 0.68 1.09
5 CD180 FOS IL1B LY96 NFKBIL1 TAB1 TLR7 RPLPO
2.57 1.18 12.43 1.02 0.27 0.83 7.73 0.79
6 CD80 HMGB1 IL2 MAP2K3 NFRKB TBK1 TLR8  
2.57 0.65 0.82 1.10 0.86 0.71 0.55
7 CD86 HRAS IL6 MAP2K4 NR2C2 TICAM1 TLR9  
0.82 0.27 21.55 0.95 0.85 1.58 0.71
8 CHUK HSP1A1 IL8 MAP3K1 PELT1 TICAM2 TNF  
1.01 1.12 19.37 0.89 1.23 0.75 2.50
9 CLEC4E HSPD1 IRAK1 MAP3K7 PPARA TIRAP TNFRSF1A  
0.82 0.82 0.91 0.96 0.79 0.88 1.07
10 CSF2 IFNA1 IRAK2 MAP4K4 PRKRA TLR1 TOLLIP  
9.57 0.89 1.79 0.87 1.03 0.48 1.58
11 CSF3 IFNB1 IRAK4 MAPK8 PTGS2 TLR10 TRAF6  
43.95 1.42 1.58 0.86 4.75 0.30 0.91
12 CXCL10 IFNG IRF1 MAPK8IP3 REL TLR2 UBE2N  
217.01 0.82 2.03 0.74 1.19 5.64 0.94
  1. MSCs were treated with or without 200 μg/ml A549 cell-derived exosomes for 24 h. Total RNA were analyzed using human toll-like receptor signaling pathway array. Fold change of RNA expression was used for 3D profile (200–24 h/0–24 h)