Fig. 7From: Superior anti-tumor activity of the MDM2 antagonist idasanutlin and the Bcl-2 inhibitor venetoclax in p53 wild-type acute myeloid leukemia modelsshRNA inhibition of Mcl-1 gene expression in MV4-11 cells a Western blot analysis of Mcl-1 protein expression and b viability of shRNA transduced cells measured by trypan blue exclusion, confirming that Mcl-1 contributes significantly to AML cell survivalBack to article page