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Table 3 Telomere lengths according to gene mutations or cytogenetic changes

From: Short telomere length and its correlation with gene mutations in myelodysplastic syndrome

Gene or cytogenetic changes Number Mean age P value Telomere lengths (T/C ratio)
Minimum P value Q1 P value Median P value Average P value Average of 0–10 percentile P value Standard deviation P value Cells under the 10th percentile of normal control (%) P value
Any gene mutation Mut(+) 45 65.4 ± 12.2 0.356 2.14 ± 1.53 0.043 5.82 ± 3.07 0.041 8.99 ± 4.17 0.025 10.68 ± 4.56 0.014 3.18 ± 1.82 0.030 7.12 ± 2.97 0.007 48.2 ± 23.6 0.017
  Mut(−) 13 57.9 ± 20.6   1.38 ± 1.11   4.34 ± 2.80   7.12 ± 5.26   8.00 ± 4.90   2.14 ± 1.32   5.13 ± 2.74   65.8 ± 25.5  
ASXL1 Mut(+) 13 65.4 ± 10.8 0.837 2.13 ± 2.29 0.461 5.32 ± 3.79 0.557 8.04 ± 4.83 0.595 9.39 ± 5.20 0.450 2.97 ± 2.28 0.689 5.78 ± 2.40 0.310 57.4 ± 24.4 0.396
  Mut(−) 45 63.2 ± 15.7   1.92 ± 1.17   5.54 ± 2.85   8.72 ± 4.39   10.28 ± 4.63   2.94 ± 1.62   6.93 ± 3.15   50.6 ± 25.1  
CSF3R Mut(+) 3 57.3 ± 21.1 0.438 2.21 ± 0.99 0.438 7.87 ± 2.87 0.087 12.43 ± 3.71 0.062 14.23 ± 4.18 0.067 3.82 ± 2.29 0.459 9.23 ± 2.43 0.119 23.9 ± 13.8 0.037
  Mut(−) 55 64.0 ± 14.4   1.96 ± 1.50   5.36 ± 3.03   8.36 ± 4.42   9.86 ± 4.69   2.90 ± 1.74   6.53 ± 3.00   53.7 ± 24.5  
DNMT3A Mut(+) 7 72.0 ± 8.9 0.117 1.66 ± 0.77 1.000 4.38 ± 1.25 0.439 6.77 ± 1.58 0.425 8.14 ± 1.66 0.453 2.50 ± 0.75 0.907 5.43 ± 1.88 0.779 55.6 ± 15.4 0.312
  Mut(−) 51 62.6 ± 15.0   2.01 ± 1.55   5.65 ± 3.20   8.82 ± 4.67   10.35 ± 4.96   3.01 ± 1.86   6.84 ± 3.12   51.7 ± 26.0  
EZH2 Mut(+) 3 71.7 ± 0.6 0.240 3.95 ± 3.95 0.379 7.71 ± 5.74 0.547 10.66 ± 6.28 0.525 12.57 ± 7.71 0.502 4.44 ± 3.43 0.342 7.13 ± 3.97 0.869 62.3 ± 12.5 0.594
  Mut(−) 55 63.3 ± 14.9   1.86 ± 1.22   5.37 ± 2.88   8.45 ± 4.39   9.95 ± 4.59   2.87 ± 1.65   6.65 ± 3.00   51.6 ± 25.4  
IDH2 Mut(+) 3 66.7 ± 9.1 0.843 3.08 ± 2.20 0.232 6.18 ± 4.53 0.974 10.04 ± 6.42 0.715 11.70 ± 5.50 0.570 3.91 ± 2.73 0.525 8.05 ± 0.99 0.232 38.7 ± 29.1 0.525
  Mut(−) 55 63.5 ± 14.9   1.91 ± 1.43   5.46 ± 3.00   8.49 ± 4.39   9.99 ± 4.73   2.90 ± 1.72   6.60 ± 3.08   52.9 ± 24.8  
NOTCH1 Mut(+) 4 64.0 ± 17.1 0.824 2.47 ± 0.84 0.189 8.01 ± 4.97 0.348 11.94 ± 7.12 0.363 14.43 ± 7.72 0.236 4.24 ± 2.29 0.248 9.48 ± 3.33 0.067 35.3 ± 31.7 0.332
  Mut(−) 54 63.7 ± 14.6   1.93 ± 1.51   5.31 ± 2.84   8.32 ± 4.19   9.76 ± 4.38   2.85 ± 1.71   6.46 ± 2.92   53.4 ± 24.2  
PLEKHG5 Mut(+) 3 58.7 ± 10.3 0.324 1.01 ± 0.52 0.158 2.86 ± 2.05 0.111 5.07 ± 2.45 0.138 6.99 ± 3.37 0.291 1.57 ± 1.17 0.119 5.95 ± 2.90 0.843 70.3 ± 18.0 0.193
  Mut(−) 55 64.0 ± 14.9   2.02 ± 1.49   5.64 ± 3.04   8.76 ± 4.47   10.25 ± 4.76   3.02 ± 1.77   6.71 ± 3.04   51.1 ± 25.0  
RUNX1 Mut(+) 3 56.7 ± 10.6 0.193 2.13 ± 1.27 0.690 4.90 ± 1.76 0.843 10.16 ± 5.47 0.641 11.73 ± 5.44 0.570 2.83 ± 0.92 0.766 8.91 ± 4.08 0.193 58.0 ± 14.9 0.641
  Mut(−) 55 64.1 ± 14.8   1.96 ± 1.49   5.53 ± 3.11   8.48 ± 4.44   9.99 ± 4.73   2.95 ± 1.80   6.55 ± 2.95   51.8 ± 25.4  
SETBP1 Mut(+) 3 66.7 ± 20.0 0.895 1.76 ± 0.32 0.690 4.20 ± 1.02 0.547 6.48 ± 1.80 0.594 7.61 ± 2.03 0.459 2.41 ± 0.43 0.869 4.76 ± 2.01 0.246 58.6 ± 18.7 0.690
  Mut(−) 55 63.5 ± 14.5   1.98 ± 1.51   5.56 ± 3.11   8.68 ± 4.54   10.22 ± 4.81   2.98 ± 1.81   6.78 ± 3.04   51.8 ± 25.3  
SF3B1 Mut(+) 5 63.6 ± 11.2 0.788 2.09 ± 1.60 0.872 5.13 ± 1.68 0.747 7.99 ± 2.51 0.851 9.87 ± 3.23 0.768 2.72 ± 1.48 0.893 7.79 ± 3.99 0.553 47.2 ± 19.2 0.517
  Mut(−) 53 63.7 ± 15.0   1.96 ± 1.48   5.53 ± 3.16   8.62 ± 4.61   10.10 ± 4.87   2.97 ± 1.80   6.57 ± 2.94   52.6 ± 25.5  
SRSF2 Mut(+) 6 73.8 ± 8.0 0.101 2.40 ± 1.72 0.446 6.47 ± 3.76 0.558 10.10 ± 5.48 0.446 11.42 ± 5.68 0.508 3.70 ± 2.26 0.374 6.89 ± 2.55 0.737 42.4 ± 30.5 0.416
  Mut(−) 52 62.5 ± 14.8   1.92 ± 1.45   5.38 ± 2.98   8.39 ± 4.35   9.93 ± 4.65   2.86 ± 1.70   6.65 ± 3.09   53.2 ± 24.3  
TET2 Mut(+) 5 75.8 ± 6.1 0.021 2.85 ± 1.69 0.131 7.06 ± 2.70 0.086 10.06 ± 2.89 0.162 12.11 ± 3.22 0.138 3.91 ± 1.91 0.154 8.19 ± 3.81 0.316 33.4 ± 18.5 0.076
  Mut(−) 53 62.6 ± 14.7   1.89 ± 1.44   5.35 ± 3.06   8.43 ± 4.57   9.89 ± 4.83   2.86 ± 1.74   6.53 ± 2.94   53.9 ± 24.8  
TP53 Mut(+) 8 69.0 ± 8.9 0.471 1.81 ± 1.23 0.748 5.12 ± 3.06 0.974 8.44 ± 4.08 0.748 10.25 ± 4.36 0.650 2.67 ± 1.84 0.471 7.62 ± 3.05 0.260 47.2 ± 27.0 0.471
  Mut(−) 50 62.8 ± 15.3   1.99 ± 1.52   5.55 ± 3.07   8.59 ± 4.55   10.05 ± 4.83   2.99 ± 1.77   6.52 ± 3.01   52.9 ± 24.7  
U2AF1 Mut(+) 9 59.4 ± 12.7 0.179 2.02 ± 1.01 0.408 6.62 ± 3.49 0.225 10.39 ± 5.60 0.269 12.08 ± 6.35 0.318 3.49 ± 1.69 0.201 7.77 ± 4.21 0.512 47.6 ± 27.7 0.614
  Mut(−) 49 64.5 ± 15.0   1.96 ± 1.55   5.29 ± 2.95   8.23 ± 4.20   9.71 ± 4.36   2.85 ± 1.78   6.47 ± 2.75   53.0 ± 24.6  
Karyotype Normal 25 61.2 ± 15.1 0.416 2.00 ± 1.95 0.237 5.32 ± 3.44 0.385 7.95 ± 4.46 0.274 9.36 ± 4.93 0.222 2.93 ± 2.09 0.459 6.08 ± 3.01 0.216 57.7 ± 26.6 0.123
  Abnormal 32 65.3 ± 14.3   1.92 ± 1.02   5.64 ± 2.80   9.00 ± 4.53   10.53 ± 4.61   2.94 ± 1.53   7.00 ± 2.96   48.3 ± 23.3  
del(5q)/−5 (+) 6 68.7 ± 13.3 0.393 2.18 ± 1.20 0.500 6.71 ± 3.56 0.393 10.28 ± 4.58 0.233 12.33 ± 4.40 0.177 3.78 ± 2.16 0.352 8.39 ± 2.36 0.048 35.4 ± 28.4 0.089
  (−) 51 62.9 ± 14.9   1.93 ± 1.52   5.35 ± 3.02   8.34 ± 4.48   9.75 ± 4.76   2.84 ± 1.73   6.39 ± 3.00   54.4 ± 24.1  
del(7q)/−7 (+) 8 61.5 ± 18.6 0.866 2.13 ± 1.05 0.302 6.58 ± 3.00 0.111 10.44 ± 5.45 0.175 11.59 ± 4.90 0.207 3.25 ± 1.51 0.261 7.06 ± 2.96 0.449 39.8 ± 24.2 0.096
  (−) 49 63.8 ± 14.2   1.93 ± 1.55   5.32 ± 3.08   8.23 ± 4.30   9.76 ± 4.73   2.89 ± 1.83   6.52 ± 3.02   54.5 ± 24.80  
Trisomy 8 (+) 8 54.4 ± 20.5 0.123 1.87 ± 1.02 0.778 6.35 ± 3.84 0.628 11.09 ± 6.69 0.261 12.35 ± 6.63 0.291 2.95 ± 1.64 0.813 8.29 ± 4.26 0.302 51.3 ± 27.8 0.919
  (−) 49 65.0 ± 13.2   1.97 ± 1.56   5.36 ± 2.96   8.12 ± 3.97   9.64 ± 4.34   2.94 ± 1.82   6.32 ± 2.69   52.6 ± 24.8  
Abn 17p (+) 3 72.3 ± 10.1 0.307 2.72 ± 1.47 0.324 6.05 ± 3.84 0.749 8.89 ± 5.48 0.906 10.34 ± 5.00 0.880 3.72 ± 2.24 0.599 6.25 ± 1.63 0.801 45.4 ± 33.9 0.623
  (−) 54 63.0 ± 14.8   1.91 ± 1.49   5.47 ± 3.07   8.52 ± 4.49   10.00 ± 4.78   2.90 ± 1.77   6.62 ± 3.06   52.8 ± 24.8  
del(20q) (+) 5 68.0 ± 10.7 0.632 2.16 ± 0.55 0.186 5.56 ± 1.41 0.519 8.13 ± 2.15 0.795 9.70 ± 2.27 0.712 3.13 ± 0.73 0.262 6.12 ± 1.28 0.880 44.4 ± 15.0 0.327
  (−) 52 63.1 ± 15.0   1.94 ± 1.55   5.49 ± 3.20   8.58 ± 4.66   10.05 ± 4.94   2.92 ± 1.85   6.65 ± 3.11   53.2 ± 25.8  
FISH 1 (+) 5 54.0 ± 25.2 0.428 1.61 ± 1.04 0.562 7.03 ± 4.89 0.586 11.77 ± 7.84 0.368 13.19 ± 7.37 0.349 2.92 ± 2.09 0.903 8.99 ± 3.72 0.128 40.4 ± 29.4 0.314
  (−) 40 63.0 ± 13.9   1.89 ± 1.18   5.49 ± 3.20   8.28 ± 3.98   9.71 ± 4.24   2.86 ± 1.64   6.34 ± 2.72   51.9 ± 25.4  
FISH 5 (+) 8 67.3 ± 9.8 0.485 1.80 ± 1.20 0.765 5.60 ± 3.63 0.921 9.17 ± 4.77 0.559 10.97 ± 4.87 0.450 2.92 ± 2.23 0.579 7.86 ± 2.91 0.123 43.4 ± 30.7 0.338
  (−) 38 61.3 ± 16.2   1.85 ± 1.15   5.45 ± 2.86   8.55 ± 4.52   9.88 ± 4.64   2.87 ± 1.54   6.33 ± 2.87   52.1 ± 24.5  
FISH 7 (+) 9 69.3 ± 7.0 0.160 1.94 ± 1.08 0.605 5.57 ± 2.66 0.478 8.54 ± 3.65 0.643 10.08 ± 4.10 0.723 2.92 ± 1.63 0.870 6.69 ± 2.74 0.786 44.4 ± 15.04 0.461
  (−) 37 60.6 ± 16.4   1.82 ± 1.18   5.46 ± 3.06   8.68 ± 4.75   10.07 ± 4.83   2.87 ± 1.67   6.58 ± 2.98   53.2 ± 25.8  
FISH 8 (+) 7 59.6 ± 15.5 0.490 1.90 ± 1.10 0.858 5.77 ± 3.74 1.000 9.70 ± 5.85 0.697 11.43 ± 6.59 0.697 3.01 ± 1.76 0.881 7.90 ± 4.44 0.549 55.6 ± 27.2 0.549
  (−) 39 62.8 ± 15.5   1.83 ± 1.17   5.43 ± 2.86   8.47 ± 4.30   9.82 ± 4.29   2.85 ± 1.65   6.37 ± 2.55   49.7 ± 25.5  
FISH 20 (+) 4 64.3 ± 7.6 0.985 2.37 ± 1.03 0.173 5.82 ± 1.49 0.417 8.38 ± 2.22 0.721 9.85 ± 2.20 0.721 3.35 ± 1.06 0.229 6.02 ± 1.08 0.895 44.0 ± 15.3 0.510
  (−) 42 62.0 ± 15.8   1.78 ± 1.17   5.39 ± 3.10   8.60 ± 4.74   10.00 ± 4.89   2.79 ± 1.70   6.62 ± 3.06   52.0 ± 26.7