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Table 3 Telomere lengths according to gene mutations or cytogenetic changes

From: Short telomere length and its correlation with gene mutations in myelodysplastic syndrome

Gene or cytogenetic changes

Number

Mean age

P value

Telomere lengths (T/C ratio)

Minimum

P value

Q1

P value

Median

P value

Average

P value

Average of 0–10 percentile

P value

Standard deviation

P value

Cells under the 10th percentile of normal control (%)

P value

Any gene mutation

Mut(+)

45

65.4 ± 12.2

0.356

2.14 ± 1.53

0.043

5.82 ± 3.07

0.041

8.99 ± 4.17

0.025

10.68 ± 4.56

0.014

3.18 ± 1.82

0.030

7.12 ± 2.97

0.007

48.2 ± 23.6

0.017

 

Mut(−)

13

57.9 ± 20.6

 

1.38 ± 1.11

 

4.34 ± 2.80

 

7.12 ± 5.26

 

8.00 ± 4.90

 

2.14 ± 1.32

 

5.13 ± 2.74

 

65.8 ± 25.5

 

ASXL1

Mut(+)

13

65.4 ± 10.8

0.837

2.13 ± 2.29

0.461

5.32 ± 3.79

0.557

8.04 ± 4.83

0.595

9.39 ± 5.20

0.450

2.97 ± 2.28

0.689

5.78 ± 2.40

0.310

57.4 ± 24.4

0.396

 

Mut(−)

45

63.2 ± 15.7

 

1.92 ± 1.17

 

5.54 ± 2.85

 

8.72 ± 4.39

 

10.28 ± 4.63

 

2.94 ± 1.62

 

6.93 ± 3.15

 

50.6 ± 25.1

 

CSF3R

Mut(+)

3

57.3 ± 21.1

0.438

2.21 ± 0.99

0.438

7.87 ± 2.87

0.087

12.43 ± 3.71

0.062

14.23 ± 4.18

0.067

3.82 ± 2.29

0.459

9.23 ± 2.43

0.119

23.9 ± 13.8

0.037

 

Mut(−)

55

64.0 ± 14.4

 

1.96 ± 1.50

 

5.36 ± 3.03

 

8.36 ± 4.42

 

9.86 ± 4.69

 

2.90 ± 1.74

 

6.53 ± 3.00

 

53.7 ± 24.5

 

DNMT3A

Mut(+)

7

72.0 ± 8.9

0.117

1.66 ± 0.77

1.000

4.38 ± 1.25

0.439

6.77 ± 1.58

0.425

8.14 ± 1.66

0.453

2.50 ± 0.75

0.907

5.43 ± 1.88

0.779

55.6 ± 15.4

0.312

 

Mut(−)

51

62.6 ± 15.0

 

2.01 ± 1.55

 

5.65 ± 3.20

 

8.82 ± 4.67

 

10.35 ± 4.96

 

3.01 ± 1.86

 

6.84 ± 3.12

 

51.7 ± 26.0

 

EZH2

Mut(+)

3

71.7 ± 0.6

0.240

3.95 ± 3.95

0.379

7.71 ± 5.74

0.547

10.66 ± 6.28

0.525

12.57 ± 7.71

0.502

4.44 ± 3.43

0.342

7.13 ± 3.97

0.869

62.3 ± 12.5

0.594

 

Mut(−)

55

63.3 ± 14.9

 

1.86 ± 1.22

 

5.37 ± 2.88

 

8.45 ± 4.39

 

9.95 ± 4.59

 

2.87 ± 1.65

 

6.65 ± 3.00

 

51.6 ± 25.4

 

IDH2

Mut(+)

3

66.7 ± 9.1

0.843

3.08 ± 2.20

0.232

6.18 ± 4.53

0.974

10.04 ± 6.42

0.715

11.70 ± 5.50

0.570

3.91 ± 2.73

0.525

8.05 ± 0.99

0.232

38.7 ± 29.1

0.525

 

Mut(−)

55

63.5 ± 14.9

 

1.91 ± 1.43

 

5.46 ± 3.00

 

8.49 ± 4.39

 

9.99 ± 4.73

 

2.90 ± 1.72

 

6.60 ± 3.08

 

52.9 ± 24.8

 

NOTCH1

Mut(+)

4

64.0 ± 17.1

0.824

2.47 ± 0.84

0.189

8.01 ± 4.97

0.348

11.94 ± 7.12

0.363

14.43 ± 7.72

0.236

4.24 ± 2.29

0.248

9.48 ± 3.33

0.067

35.3 ± 31.7

0.332

 

Mut(−)

54

63.7 ± 14.6

 

1.93 ± 1.51

 

5.31 ± 2.84

 

8.32 ± 4.19

 

9.76 ± 4.38

 

2.85 ± 1.71

 

6.46 ± 2.92

 

53.4 ± 24.2

 

PLEKHG5

Mut(+)

3

58.7 ± 10.3

0.324

1.01 ± 0.52

0.158

2.86 ± 2.05

0.111

5.07 ± 2.45

0.138

6.99 ± 3.37

0.291

1.57 ± 1.17

0.119

5.95 ± 2.90

0.843

70.3 ± 18.0

0.193

 

Mut(−)

55

64.0 ± 14.9

 

2.02 ± 1.49

 

5.64 ± 3.04

 

8.76 ± 4.47

 

10.25 ± 4.76

 

3.02 ± 1.77

 

6.71 ± 3.04

 

51.1 ± 25.0

 

RUNX1

Mut(+)

3

56.7 ± 10.6

0.193

2.13 ± 1.27

0.690

4.90 ± 1.76

0.843

10.16 ± 5.47

0.641

11.73 ± 5.44

0.570

2.83 ± 0.92

0.766

8.91 ± 4.08

0.193

58.0 ± 14.9

0.641

 

Mut(−)

55

64.1 ± 14.8

 

1.96 ± 1.49

 

5.53 ± 3.11

 

8.48 ± 4.44

 

9.99 ± 4.73

 

2.95 ± 1.80

 

6.55 ± 2.95

 

51.8 ± 25.4

 

SETBP1

Mut(+)

3

66.7 ± 20.0

0.895

1.76 ± 0.32

0.690

4.20 ± 1.02

0.547

6.48 ± 1.80

0.594

7.61 ± 2.03

0.459

2.41 ± 0.43

0.869

4.76 ± 2.01

0.246

58.6 ± 18.7

0.690

 

Mut(−)

55

63.5 ± 14.5

 

1.98 ± 1.51

 

5.56 ± 3.11

 

8.68 ± 4.54

 

10.22 ± 4.81

 

2.98 ± 1.81

 

6.78 ± 3.04

 

51.8 ± 25.3

 

SF3B1

Mut(+)

5

63.6 ± 11.2

0.788

2.09 ± 1.60

0.872

5.13 ± 1.68

0.747

7.99 ± 2.51

0.851

9.87 ± 3.23

0.768

2.72 ± 1.48

0.893

7.79 ± 3.99

0.553

47.2 ± 19.2

0.517

 

Mut(−)

53

63.7 ± 15.0

 

1.96 ± 1.48

 

5.53 ± 3.16

 

8.62 ± 4.61

 

10.10 ± 4.87

 

2.97 ± 1.80

 

6.57 ± 2.94

 

52.6 ± 25.5

 

SRSF2

Mut(+)

6

73.8 ± 8.0

0.101

2.40 ± 1.72

0.446

6.47 ± 3.76

0.558

10.10 ± 5.48

0.446

11.42 ± 5.68

0.508

3.70 ± 2.26

0.374

6.89 ± 2.55

0.737

42.4 ± 30.5

0.416

 

Mut(−)

52

62.5 ± 14.8

 

1.92 ± 1.45

 

5.38 ± 2.98

 

8.39 ± 4.35

 

9.93 ± 4.65

 

2.86 ± 1.70

 

6.65 ± 3.09

 

53.2 ± 24.3

 

TET2

Mut(+)

5

75.8 ± 6.1

0.021

2.85 ± 1.69

0.131

7.06 ± 2.70

0.086

10.06 ± 2.89

0.162

12.11 ± 3.22

0.138

3.91 ± 1.91

0.154

8.19 ± 3.81

0.316

33.4 ± 18.5

0.076

 

Mut(−)

53

62.6 ± 14.7

 

1.89 ± 1.44

 

5.35 ± 3.06

 

8.43 ± 4.57

 

9.89 ± 4.83

 

2.86 ± 1.74

 

6.53 ± 2.94

 

53.9 ± 24.8

 

TP53

Mut(+)

8

69.0 ± 8.9

0.471

1.81 ± 1.23

0.748

5.12 ± 3.06

0.974

8.44 ± 4.08

0.748

10.25 ± 4.36

0.650

2.67 ± 1.84

0.471

7.62 ± 3.05

0.260

47.2 ± 27.0

0.471

 

Mut(−)

50

62.8 ± 15.3

 

1.99 ± 1.52

 

5.55 ± 3.07

 

8.59 ± 4.55

 

10.05 ± 4.83

 

2.99 ± 1.77

 

6.52 ± 3.01

 

52.9 ± 24.7

 

U2AF1

Mut(+)

9

59.4 ± 12.7

0.179

2.02 ± 1.01

0.408

6.62 ± 3.49

0.225

10.39 ± 5.60

0.269

12.08 ± 6.35

0.318

3.49 ± 1.69

0.201

7.77 ± 4.21

0.512

47.6 ± 27.7

0.614

 

Mut(−)

49

64.5 ± 15.0

 

1.96 ± 1.55

 

5.29 ± 2.95

 

8.23 ± 4.20

 

9.71 ± 4.36

 

2.85 ± 1.78

 

6.47 ± 2.75

 

53.0 ± 24.6

 

Karyotype

Normal

25

61.2 ± 15.1

0.416

2.00 ± 1.95

0.237

5.32 ± 3.44

0.385

7.95 ± 4.46

0.274

9.36 ± 4.93

0.222

2.93 ± 2.09

0.459

6.08 ± 3.01

0.216

57.7 ± 26.6

0.123

 

Abnormal

32

65.3 ± 14.3

 

1.92 ± 1.02

 

5.64 ± 2.80

 

9.00 ± 4.53

 

10.53 ± 4.61

 

2.94 ± 1.53

 

7.00 ± 2.96

 

48.3 ± 23.3

 

del(5q)/−5

(+)

6

68.7 ± 13.3

0.393

2.18 ± 1.20

0.500

6.71 ± 3.56

0.393

10.28 ± 4.58

0.233

12.33 ± 4.40

0.177

3.78 ± 2.16

0.352

8.39 ± 2.36

0.048

35.4 ± 28.4

0.089

 

(−)

51

62.9 ± 14.9

 

1.93 ± 1.52

 

5.35 ± 3.02

 

8.34 ± 4.48

 

9.75 ± 4.76

 

2.84 ± 1.73

 

6.39 ± 3.00

 

54.4 ± 24.1

 

del(7q)/−7

(+)

8

61.5 ± 18.6

0.866

2.13 ± 1.05

0.302

6.58 ± 3.00

0.111

10.44 ± 5.45

0.175

11.59 ± 4.90

0.207

3.25 ± 1.51

0.261

7.06 ± 2.96

0.449

39.8 ± 24.2

0.096

 

(−)

49

63.8 ± 14.2

 

1.93 ± 1.55

 

5.32 ± 3.08

 

8.23 ± 4.30

 

9.76 ± 4.73

 

2.89 ± 1.83

 

6.52 ± 3.02

 

54.5 ± 24.80

 

Trisomy 8

(+)

8

54.4 ± 20.5

0.123

1.87 ± 1.02

0.778

6.35 ± 3.84

0.628

11.09 ± 6.69

0.261

12.35 ± 6.63

0.291

2.95 ± 1.64

0.813

8.29 ± 4.26

0.302

51.3 ± 27.8

0.919

 

(−)

49

65.0 ± 13.2

 

1.97 ± 1.56

 

5.36 ± 2.96

 

8.12 ± 3.97

 

9.64 ± 4.34

 

2.94 ± 1.82

 

6.32 ± 2.69

 

52.6 ± 24.8

 

Abn 17p

(+)

3

72.3 ± 10.1

0.307

2.72 ± 1.47

0.324

6.05 ± 3.84

0.749

8.89 ± 5.48

0.906

10.34 ± 5.00

0.880

3.72 ± 2.24

0.599

6.25 ± 1.63

0.801

45.4 ± 33.9

0.623

 

(−)

54

63.0 ± 14.8

 

1.91 ± 1.49

 

5.47 ± 3.07

 

8.52 ± 4.49

 

10.00 ± 4.78

 

2.90 ± 1.77

 

6.62 ± 3.06

 

52.8 ± 24.8

 

del(20q)

(+)

5

68.0 ± 10.7

0.632

2.16 ± 0.55

0.186

5.56 ± 1.41

0.519

8.13 ± 2.15

0.795

9.70 ± 2.27

0.712

3.13 ± 0.73

0.262

6.12 ± 1.28

0.880

44.4 ± 15.0

0.327

 

(−)

52

63.1 ± 15.0

 

1.94 ± 1.55

 

5.49 ± 3.20

 

8.58 ± 4.66

 

10.05 ± 4.94

 

2.92 ± 1.85

 

6.65 ± 3.11

 

53.2 ± 25.8

 

FISH 1

(+)

5

54.0 ± 25.2

0.428

1.61 ± 1.04

0.562

7.03 ± 4.89

0.586

11.77 ± 7.84

0.368

13.19 ± 7.37

0.349

2.92 ± 2.09

0.903

8.99 ± 3.72

0.128

40.4 ± 29.4

0.314

 

(−)

40

63.0 ± 13.9

 

1.89 ± 1.18

 

5.49 ± 3.20

 

8.28 ± 3.98

 

9.71 ± 4.24

 

2.86 ± 1.64

 

6.34 ± 2.72

 

51.9 ± 25.4

 

FISH 5

(+)

8

67.3 ± 9.8

0.485

1.80 ± 1.20

0.765

5.60 ± 3.63

0.921

9.17 ± 4.77

0.559

10.97 ± 4.87

0.450

2.92 ± 2.23

0.579

7.86 ± 2.91

0.123

43.4 ± 30.7

0.338

 

(−)

38

61.3 ± 16.2

 

1.85 ± 1.15

 

5.45 ± 2.86

 

8.55 ± 4.52

 

9.88 ± 4.64

 

2.87 ± 1.54

 

6.33 ± 2.87

 

52.1 ± 24.5

 

FISH 7

(+)

9

69.3 ± 7.0

0.160

1.94 ± 1.08

0.605

5.57 ± 2.66

0.478

8.54 ± 3.65

0.643

10.08 ± 4.10

0.723

2.92 ± 1.63

0.870

6.69 ± 2.74

0.786

44.4 ± 15.04

0.461

 

(−)

37

60.6 ± 16.4

 

1.82 ± 1.18

 

5.46 ± 3.06

 

8.68 ± 4.75

 

10.07 ± 4.83

 

2.87 ± 1.67

 

6.58 ± 2.98

 

53.2 ± 25.8

 

FISH 8

(+)

7

59.6 ± 15.5

0.490

1.90 ± 1.10

0.858

5.77 ± 3.74

1.000

9.70 ± 5.85

0.697

11.43 ± 6.59

0.697

3.01 ± 1.76

0.881

7.90 ± 4.44

0.549

55.6 ± 27.2

0.549

 

(−)

39

62.8 ± 15.5

 

1.83 ± 1.17

 

5.43 ± 2.86

 

8.47 ± 4.30

 

9.82 ± 4.29

 

2.85 ± 1.65

 

6.37 ± 2.55

 

49.7 ± 25.5

 

FISH 20

(+)

4

64.3 ± 7.6

0.985

2.37 ± 1.03

0.173

5.82 ± 1.49

0.417

8.38 ± 2.22

0.721

9.85 ± 2.20

0.721

3.35 ± 1.06

0.229

6.02 ± 1.08

0.895

44.0 ± 15.3

0.510

 

(−)

42

62.0 ± 15.8

 

1.78 ± 1.17

 

5.39 ± 3.10

 

8.60 ± 4.74

 

10.00 ± 4.89

 

2.79 ± 1.70

 

6.62 ± 3.06

 

52.0 ± 26.7

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